Isolation and Characterization of Two Antimicrobial Agents from Mace (Myristica fragrans)

The two antimicrobial resorcinols malabaricone B [1] and malabaricone C [2] were isolated from mace, the dried seed covers of Myristica fragrans. Both compounds exhibited strong antifungal and antibacterial activities. Structure modifications by methylation or reduction resulted in diminished activi...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1991-05, Vol.54 (3), p.856-859
Main Authors: Orabi, Khaled Y, Mossa, Jaber S, El-Feraly, Farouk S
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemistry
Anti-Infective Agents - isolation & purification
ANTIBACTERIAL PROPERTIES
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
ANTIFUNGAL PROPERTIES
ANTIMICROBIAL PROPERTIES
Biological and medical sciences
COMPOSE PHENOLIQUE
COMPUESTOS FENOLICOS
General pharmacology
malabaricone b
malibaricone c
Medical sciences
Microbial Sensitivity Tests
MOLECULAR CONFORMATION
MYRISTICA FRAGRANS
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PHENOLIC COMPOUNDS
Plants, Medicinal
PROPIEDADES ANTIMICOSICAS
PROPIEDADES ANTIMICROBIANAS
PROPRIETE ANTIFONGIQUE
PROPRIETE ANTIMICROBIENNE
RESORCINOLS
Resorcinols - chemistry
Resorcinols - isolation & purification
Resorcinols - pharmacology
STRUCTURE
STRUCTURE ACTIVITY RELATIONSHIPS
Structure-Activity Relationship
TESTA
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Description
Summary:The two antimicrobial resorcinols malabaricone B [1] and malabaricone C [2] were isolated from mace, the dried seed covers of Myristica fragrans. Both compounds exhibited strong antifungal and antibacterial activities. Structure modifications by methylation or reduction resulted in diminished activity.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50075a017