Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis

Based on the concept that proteolytic enzymes, like cathepsins, are associated with tissue destruction, we investigated the expression of the matrix‐degrading cysteine proteinase cathepsin B in synovial tissues from the joints of patients with rheumatoid arthritis. The data indicate an enhanced tran...

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Bibliographic Details
Published in:Arthritis and rheumatism 1991-11, Vol.34 (11), p.1444-1451
Main Authors: Trabandt, Andreas, Gay, Renate E., Fassbender, Hans‐Georg, Gay, Steffen
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - enzymology
Biological and medical sciences
Cathepsin B - genetics
Cathepsin B - metabolism
Cells, Cultured
Diseases of the osteoarticular system
Fluorescent Antibody Technique
Humans
Inflammatory joint diseases
Medical sciences
Nucleic Acid Hybridization
RNA, Messenger - analysis
Synovial Membrane - enzymology
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Summary:Based on the concept that proteolytic enzymes, like cathepsins, are associated with tissue destruction, we investigated the expression of the matrix‐degrading cysteine proteinase cathepsin B in synovial tissues from the joints of patients with rheumatoid arthritis. The data indicate an enhanced transcription of cathepsin B in synovial cells when compared with normal fibroblasts, cathepsin B‐producing epithelial tumor cells (SW1116), or fibroblasts derived from inflamed tonsils. Immunolocalization of cathepsin B appeared to be restricted mainly to the synovial cells attached to cartilage and bone at sites of rheumatoid joint erosion.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780341116