Parvovirus B19 transmitted by bone marrow

We describe a case of symptomatic parvovirus B19 infection transmitted by bone marrow (BM). The infection caused prolonged anaemia, thrombocytopenia, arthralgia and erythema infectiosum in a 16-year-old girl with acute myeloid leukaemia receiving a BM transplant (BMT). The BM donor was a 19-year-old...

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Bibliographic Details
Published in:British journal of haematology 2000-11, Vol.111 (2), p.659-661
Main Authors: HEEGAARD, Erik D, PETERSEN, Bodil Laub
Format: Article
Language:English
Subjects:
Adolescent
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antigens, Viral - analysis
Biological and medical sciences
Bone Marrow Transplantation - adverse effects
Bone marrow, stem cells transplantation. Graft versus host reaction
DNA, Viral - analysis
Enzyme-Linked Immunosorbent Assay
Erythema Infectiosum - transmission
Female
Hematology
Humans
Leukemia, Myeloid - surgery
Leukemia, Myeloid - virology
Male
Medical sciences
Parvovirus B19, Human
Polymerase Chain Reaction
Retrospective Studies
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary:We describe a case of symptomatic parvovirus B19 infection transmitted by bone marrow (BM). The infection caused prolonged anaemia, thrombocytopenia, arthralgia and erythema infectiosum in a 16-year-old girl with acute myeloid leukaemia receiving a BM transplant (BMT). The BM donor was a 19-year-old asymptomatic brother who had parvovirus B19 viraemia at the time of BM harvest. Sequencing of the VP2 gene from the patient and the donor showed a perfect match of DNA sequences, confirming the mode of transmission. Parvovirus B19 represents a potential complicating factor in patients undergoing BMT, but screening by polymerase chain reaction (PCR) of donor BM may reduce the risk of infection.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2000.02407.x