Changes in the firing pattern of globus pallidus neurons after the degeneration of nigrostriatal pathway are mediated by the subthalamic nucleus in the rat

Changes in the neuronal activity of globus pallidus (GP) have been shown in animal models of parkinsonism. In order to study the implication of the subthalamic nucleus (STN) in these changes, the effects of STN lesions alone or in combination with 6-hydroxydopamine (6-OHDA) -induced damage to the su...

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Bibliographic Details
Published in:The European journal of neuroscience 2000-12, Vol.12 (12), p.4338-4344
Main Authors: Ni, Z, Bouali-Benazzouz, R, Gao, D, Benabid, A L, Benazzouz, A
Format: Article
Language:English
Subjects:
Animals
Corpus Striatum - physiology
Globus Pallidus - physiology
Male
Nerve Degeneration
Neurons - cytology
Neurons - pathology
Neurons - physiology
Oxidopamine
Parkinson's disease
Rats
Rats, Wistar
Substantia Nigra - pathology
Substantia Nigra - physiology
Subthalamic Nucleus - pathology
Subthalamic Nucleus - physiology
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Summary:Changes in the neuronal activity of globus pallidus (GP) have been shown in animal models of parkinsonism. In order to study the implication of the subthalamic nucleus (STN) in these changes, the effects of STN lesions alone or in combination with 6-hydroxydopamine (6-OHDA) -induced damage to the substantia nigra compacta (SNc) were examined in rats using electrophysiological recordings of GP cells. In normal rats, the firing rate was 22.1+/-1.4 spikes/s. The pattern was regular in 45%, irregular in 49% and bursty in 6% of the cases. In rats with STN lesions, the firing rate of GP units (20.15+/-1.25 spikes/s) did not differ from that of normal rats and only regular (46%) and irregular (54%) cells were found; a bursty pattern was not observed. 6-OHDA lesions of the SNc induced no change in the firing rate of GP neurons (21.5+/-1.4 spikes/s, P>0.05) but a significant decrease in the percentage of regular cells (27%, P
ISSN:0953-816X
1460-9568
DOI:10.1046/j.1460-9568.2000.01346.x