Supratentorial ependymomas in childhood : clinicopathological findings and prognosis

Out of 29 supratentorial ependymomas in children under 10 years of age, operated on between 1951 and 1989, 18 were situated in the hemispheres and 11 in the midline. 15 of the 18 hemispheric tumours, but only 4 of the 11 intra- or paraventricular ependymomas allowed complete removal. The operative m...

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Bibliographic Details
Published in:Acta neurochirurgica 1991-01, Vol.111 (3-4), p.96-102
Main Authors: ERNESTUS, R.-I, WILCKE, O, SCHRODER, R
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Child
Child, Preschool
Combined Modality Therapy
Cranial Irradiation
Ependymoma - mortality
Ependymoma - pathology
Ependymoma - radiotherapy
Ependymoma - surgery
Female
Follow-Up Studies
Humans
Infant
Male
Medical sciences
Neurology
Postoperative Complications - mortality
Supratentorial Neoplasms - mortality
Supratentorial Neoplasms - pathology
Supratentorial Neoplasms - radiotherapy
Supratentorial Neoplasms - surgery
Survival Rate
Tumors of the nervous system. Phacomatoses
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Summary:Out of 29 supratentorial ependymomas in children under 10 years of age, operated on between 1951 and 1989, 18 were situated in the hemispheres and 11 in the midline. 15 of the 18 hemispheric tumours, but only 4 of the 11 intra- or paraventricular ependymomas allowed complete removal. The operative mortality within the observation period of nearly 40 years was 27% for tumours in the midline and 11% for those in the hemispheres. The grade of malignancy rose with increasing distance from the ventricular level. 5-year survival without recurrence was 75% in grade 2 and 31% in grade 3 ependymomas. The total rate of recurrence was 58%. New tumour growth can be delayed by postoperative irradiation, at least in grade 2 ependymomas. It can be prevented, if at all, only by total resection of the primary tumour.
ISSN:0001-6268
0942-0940
DOI:10.1007/BF01400495