The Th1-Th2 classification of cellular immune responses: concepts, current thinking and applications in haematological malignancy

The finding that T cell immune responses could be divided into those promoting cell mediated immunity (Th1) and humoral responses (Th2) has had a profound effect on the understanding of immune response generation over the last 15 years. With ever increasing knowledge of the immune system, the model...

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Bibliographic Details
Published in:Blood reviews 2000-12, Vol.14 (4), p.228-239
Main Authors: Lappin, M.B., Campbell, J.D.M.
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Biological and medical sciences
Cell interactions
Cytotoxicity, Immunologic
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hematologic and hematopoietic diseases
Hematologic Neoplasms - immunology
Humans
Immunobiology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Th1 Cells - classification
Th1 Cells - immunology
Th2 Cells - classification
Th2 Cells - immunology
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Summary:The finding that T cell immune responses could be divided into those promoting cell mediated immunity (Th1) and humoral responses (Th2) has had a profound effect on the understanding of immune response generation over the last 15 years. With ever increasing knowledge of the immune system, the model has come under criticism, as not all responses easily fit the classification. Nonetheless, the model still provides a valuable framework on which to base immunological research. In this review we update the model with current thinking regarding the generation and maintenance of immune responses. We then examine how the Th1–Th2 paradigm may be applied in developing new understanding of several topical issues in haematological malignancy—control of graft-versus–host disease; cytokine control of proliferating clones in B and T cell diseases; and suppression of T cell responses in multiple myeloma.
ISSN:0268-960X
1532-1681
DOI:10.1054/blre.2000.0136