NEW ANTITUMOR SUBSTANCES, BE-12406A AND BE-12406B, PRODUCED BY A STREPTOMYCETE: I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

New antitumor substances, designated BE-12406A and BE-12406B, were isolated from the culture broth of a streptomycete, strain BA12406. The active principles were extracted from mycelium by methanol and successively purified by silica gel column chromatography and preparative TLC. BE-12406A and BE-12...

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Bibliographic Details
Published in:Journal of antibiotics 1991/10/25, Vol.44(10), pp.1054-1060
Main Authors: KOJIRI, KATSUHISA, ARAKAWA, HIROHARU, SATOH, FUMIO, KAWAMURA, KENJI, OKURA, AKIRA, SUDA, HIROYUKI, OKANISHI, MASANORI
Format: Article
Language:English
Subjects:
Aminoglycosides
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antineoplastic agents
Biological and medical sciences
Chromatography
Doxorubicin - pharmacology
Drug Resistance
Fermentation
General aspects
Leukemia - drug therapy
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Pharmacology. Drug treatments
Spectrophotometry, Infrared
Streptomyces - classification
Streptomyces - growth & development
Streptomyces - metabolism
Streptomyces - physiology
Tumor Cells, Cultured - drug effects
Vincristine - pharmacology
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Summary:New antitumor substances, designated BE-12406A and BE-12406B, were isolated from the culture broth of a streptomycete, strain BA12406. The active principles were extracted from mycelium by methanol and successively purified by silica gel column chromatography and preparative TLC. BE-12406A and BE-12406B inhibited the growth of vincristine-resistant or doxorubicin-resistant P388 murine leukemia cell lines as well as their parent sensitive cell line. In in vivo experiments, BE-12406A inhibited the growth of S-180 murine ascites tumor.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.44.1054