Transplacental passage of mifepristone and its influence on maternal and fetal steroid concentrations in the second trimester of pregnancy

The maternal and fetal endocrine effects of the maternal administration of the anti-progestin mifepristone in mid- pregnancy have been investigated. Mifeprlstone and the metabolite RU 42,633 were detected in the fetal circulation and in the amniotic fluid 4, 24 and 48 h after oral ingestion. Maximum...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1991-03, Vol.6 (3), p.458-462
Main Authors: Hill, N.C.W., Selinger, M., Ferguson, J., MacKenzie, I.Z.
Format: Article
Language:English
Subjects:
Abortion, Induced - methods
Adult
Biological and medical sciences
Birth control
Female
Fetal Blood - metabolism
Gynecology. Andrology. Obstetrics
Humans
Induced abortion. Therapeutic abortion
Maternal-Fetal Exchange - physiology
Medical sciences
mifepristone
Mifepristone - analogs & derivatives
Mifepristone - pharmacokinetics
placental transfer
Population
Pregnancy
Pregnancy Trimester, Second - blood
RU 38
Steroids - blood
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Summary:The maternal and fetal endocrine effects of the maternal administration of the anti-progestin mifepristone in mid- pregnancy have been investigated. Mifeprlstone and the metabolite RU 42,633 were detected in the fetal circulation and in the amniotic fluid 4, 24 and 48 h after oral ingestion. Maximum fetal plasma concentrations of mifepristone occurred 4 h after treatment indicating rapid placental transfer of the drug. No significant changes in progesterone, cortisol, oestradiol or aldosterone concentrations were detected in the maternal circulation after mifepristone treatment. No significant changes occurred in the fetal progesterone, oestradiol or cortisol concentrations, but a significant Increase in fetal aldosterone occurred 4 and 24 h after treatment. The significance of these results Is discussed in relation to the possible therapeutic uses of mifepristone for Inducing labour.
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a137358