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Nuchal thickness evolution in trisomy 18 fetuses
Objective To assess the natural evolution of nuchal thickness in trisomy 18 fetuses. Methods Serial measurements of nuchal thickness were performed over a 1‐ to 5‐week period in 17 fetuses with trisomy 18, from the 10th to the 20th week of pregnancy. To avoid a confounding effect due to gestational...
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| Published in: | Ultrasound in obstetrics & gynecology 2000-08, Vol.16 (2), p.146-148 |
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| container_start_page | 146 |
| container_title | Ultrasound in obstetrics & gynecology |
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| creator | Borrell, A. Farré, M. T. Echevarría, M. Martinez, J. M. Costa, D. Fortuny, A. |
| description | Objective
To assess the natural evolution of nuchal thickness in trisomy 18 fetuses.
Methods
Serial measurements of nuchal thickness were performed over a 1‐ to 5‐week period in 17 fetuses with trisomy 18, from the 10th to the 20th week of pregnancy. To avoid a confounding effect due to gestational age, nuchal thickness was also expressed in standard deviations (SD) for the corresponding gestational week. In addition, the changes were assessed in terms of the presence of clinically positive thickening, considered as such when its measurement was above 2.5 SD for the corresponding gestational week.
Results
On the initial nuchal thickness measurement, sensitivity for trisomy 18 decreased from 66% on assessment at 10–13 weeks of gestation to 38% at 14–16 weeks. In serial determinations, a mean increase of 1.3 mm [95% confidence interval (CI), 0.1–2.5] was observed for a mean period of 21 days. When corrected for gestational age, the mean increase of 0.2 SD (95% CI, −1.2 to −1.6) was found to be non‐significant. No clinically relevant changes were recorded on re‐examination, with nuchal thickening remaining stable in 76% of cases.
Conclusion
Nuchal thickening at re‐examination was observed in a similar proportion of trisomy 18 fetuses as when initially observed. Copyright © 2000 International Society of Ultrasound in Obstetrics and Gynecology |
| doi_str_mv | 10.1046/j.1469-0705.2000.00200.x |
| format | article |
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To assess the natural evolution of nuchal thickness in trisomy 18 fetuses.
Methods
Serial measurements of nuchal thickness were performed over a 1‐ to 5‐week period in 17 fetuses with trisomy 18, from the 10th to the 20th week of pregnancy. To avoid a confounding effect due to gestational age, nuchal thickness was also expressed in standard deviations (SD) for the corresponding gestational week. In addition, the changes were assessed in terms of the presence of clinically positive thickening, considered as such when its measurement was above 2.5 SD for the corresponding gestational week.
Results
On the initial nuchal thickness measurement, sensitivity for trisomy 18 decreased from 66% on assessment at 10–13 weeks of gestation to 38% at 14–16 weeks. In serial determinations, a mean increase of 1.3 mm [95% confidence interval (CI), 0.1–2.5] was observed for a mean period of 21 days. When corrected for gestational age, the mean increase of 0.2 SD (95% CI, −1.2 to −1.6) was found to be non‐significant. No clinically relevant changes were recorded on re‐examination, with nuchal thickening remaining stable in 76% of cases.
Conclusion
Nuchal thickening at re‐examination was observed in a similar proportion of trisomy 18 fetuses as when initially observed. Copyright © 2000 International Society of Ultrasound in Obstetrics and Gynecology</description><identifier>ISSN: 0960-7692</identifier><identifier>EISSN: 1469-0705</identifier><identifier>DOI: 10.1046/j.1469-0705.2000.00200.x</identifier><identifier>PMID: 11117084</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Biological and medical sciences ; Chromosomes, Human, Pair 18 ; Edward's syndrome ; Embryonic and Fetal Development ; Female ; Fetal edema ; Fetal karyotype ; Gynecology. Andrology. Obstetrics ; Humans ; Incidence ; Management. Prenatal diagnosis ; Mass Screening - methods ; Medical sciences ; Neck - diagnostic imaging ; Neck - embryology ; Nuchal translucency ; Pregnancy ; Pregnancy Trimester, Second ; Pregnancy. Fetus. Placenta ; Retrospective Studies ; Risk Factors ; Sensitivity and Specificity ; Time Factors ; Trisomy - diagnosis ; Trisomy 18 ; Ultrasonography, Prenatal - methods ; Ultrasound</subject><ispartof>Ultrasound in obstetrics & gynecology, 2000-08, Vol.16 (2), p.146-148</ispartof><rights>Copyright © 2000 International Society of Ultrasound in Obstetrics and Gynecology</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4428-44e7399d223acbcbc505675ca90ba86042c3bac2b6687672627928b33d8f68d13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=946895$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11117084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borrell, A.</creatorcontrib><creatorcontrib>Farré, M. T.</creatorcontrib><creatorcontrib>Echevarría, M.</creatorcontrib><creatorcontrib>Martinez, J. M.</creatorcontrib><creatorcontrib>Costa, D.</creatorcontrib><creatorcontrib>Fortuny, A.</creatorcontrib><title>Nuchal thickness evolution in trisomy 18 fetuses</title><title>Ultrasound in obstetrics & gynecology</title><addtitle>Ultrasound Obstet Gynecol</addtitle><description>Objective
To assess the natural evolution of nuchal thickness in trisomy 18 fetuses.
Methods
Serial measurements of nuchal thickness were performed over a 1‐ to 5‐week period in 17 fetuses with trisomy 18, from the 10th to the 20th week of pregnancy. To avoid a confounding effect due to gestational age, nuchal thickness was also expressed in standard deviations (SD) for the corresponding gestational week. In addition, the changes were assessed in terms of the presence of clinically positive thickening, considered as such when its measurement was above 2.5 SD for the corresponding gestational week.
Results
On the initial nuchal thickness measurement, sensitivity for trisomy 18 decreased from 66% on assessment at 10–13 weeks of gestation to 38% at 14–16 weeks. In serial determinations, a mean increase of 1.3 mm [95% confidence interval (CI), 0.1–2.5] was observed for a mean period of 21 days. When corrected for gestational age, the mean increase of 0.2 SD (95% CI, −1.2 to −1.6) was found to be non‐significant. No clinically relevant changes were recorded on re‐examination, with nuchal thickening remaining stable in 76% of cases.
Conclusion
Nuchal thickening at re‐examination was observed in a similar proportion of trisomy 18 fetuses as when initially observed. Copyright © 2000 International Society of Ultrasound in Obstetrics and Gynecology</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chromosomes, Human, Pair 18</subject><subject>Edward's syndrome</subject><subject>Embryonic and Fetal Development</subject><subject>Female</subject><subject>Fetal edema</subject><subject>Fetal karyotype</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Incidence</subject><subject>Management. Prenatal diagnosis</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Neck - diagnostic imaging</subject><subject>Neck - embryology</subject><subject>Nuchal translucency</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Time Factors</subject><subject>Trisomy - diagnosis</subject><subject>Trisomy 18</subject><subject>Ultrasonography, Prenatal - methods</subject><subject>Ultrasound</subject><issn>0960-7692</issn><issn>1469-0705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqNkE1Lw0AQhhdRbK3-BQkI3hJnP7If4EWKVkHsxZ6XzWZDU_NRs4m2_97Ehnp15jCHeWZeeBAKMEQYGL_bRJhxFYKAOCIAEAH0I9qdoOlxcYqmoDiEgisyQRfeb3qQM8rP0QT3JUCyKYK3zq5NEbTr3H5UzvvAfdVF1-Z1FeRV0Da5r8t9gGWQubbzzl-is8wU3l2Nc4ZWT4_v8-fwdbl4mT-8hpYxIkPGnKBKpYRQY5O-Y4i5iK1RkBjJgRFLE2NJwrkUXBBOhCIyoTSVGZcppjN0e_i7berPzvlWl7m3rihM5erOa0GYkgwPoDyAtqm9b1ymt01emmavMejBlt7oQYoepOjBlv61pXf96fWY0SWlS_8ORz09cDMCxltTZI2pbO6PnGJcqrin7g_Ud164_b_j9Wq5iKmkPzwLgrk</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>Borrell, A.</creator><creator>Farré, M. T.</creator><creator>Echevarría, M.</creator><creator>Martinez, J. M.</creator><creator>Costa, D.</creator><creator>Fortuny, A.</creator><general>Blackwell Science Ltd</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000801</creationdate><title>Nuchal thickness evolution in trisomy 18 fetuses</title><author>Borrell, A. ; Farré, M. T. ; Echevarría, M. ; Martinez, J. M. ; Costa, D. ; Fortuny, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4428-44e7399d223acbcbc505675ca90ba86042c3bac2b6687672627928b33d8f68d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chromosomes, Human, Pair 18</topic><topic>Edward's syndrome</topic><topic>Embryonic and Fetal Development</topic><topic>Female</topic><topic>Fetal edema</topic><topic>Fetal karyotype</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Incidence</topic><topic>Management. Prenatal diagnosis</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Neck - diagnostic imaging</topic><topic>Neck - embryology</topic><topic>Nuchal translucency</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Time Factors</topic><topic>Trisomy - diagnosis</topic><topic>Trisomy 18</topic><topic>Ultrasonography, Prenatal - methods</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borrell, A.</creatorcontrib><creatorcontrib>Farré, M. T.</creatorcontrib><creatorcontrib>Echevarría, M.</creatorcontrib><creatorcontrib>Martinez, J. M.</creatorcontrib><creatorcontrib>Costa, D.</creatorcontrib><creatorcontrib>Fortuny, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borrell, A.</au><au>Farré, M. T.</au><au>Echevarría, M.</au><au>Martinez, J. M.</au><au>Costa, D.</au><au>Fortuny, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nuchal thickness evolution in trisomy 18 fetuses</atitle><jtitle>Ultrasound in obstetrics & gynecology</jtitle><addtitle>Ultrasound Obstet Gynecol</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>16</volume><issue>2</issue><spage>146</spage><epage>148</epage><pages>146-148</pages><issn>0960-7692</issn><eissn>1469-0705</eissn><abstract>Objective
To assess the natural evolution of nuchal thickness in trisomy 18 fetuses.
Methods
Serial measurements of nuchal thickness were performed over a 1‐ to 5‐week period in 17 fetuses with trisomy 18, from the 10th to the 20th week of pregnancy. To avoid a confounding effect due to gestational age, nuchal thickness was also expressed in standard deviations (SD) for the corresponding gestational week. In addition, the changes were assessed in terms of the presence of clinically positive thickening, considered as such when its measurement was above 2.5 SD for the corresponding gestational week.
Results
On the initial nuchal thickness measurement, sensitivity for trisomy 18 decreased from 66% on assessment at 10–13 weeks of gestation to 38% at 14–16 weeks. In serial determinations, a mean increase of 1.3 mm [95% confidence interval (CI), 0.1–2.5] was observed for a mean period of 21 days. When corrected for gestational age, the mean increase of 0.2 SD (95% CI, −1.2 to −1.6) was found to be non‐significant. No clinically relevant changes were recorded on re‐examination, with nuchal thickening remaining stable in 76% of cases.
Conclusion
Nuchal thickening at re‐examination was observed in a similar proportion of trisomy 18 fetuses as when initially observed. Copyright © 2000 International Society of Ultrasound in Obstetrics and Gynecology</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11117084</pmid><doi>10.1046/j.1469-0705.2000.00200.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0960-7692 |
| ispartof | Ultrasound in obstetrics & gynecology, 2000-08, Vol.16 (2), p.146-148 |
| issn | 0960-7692 1469-0705 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Biological and medical sciences Chromosomes, Human, Pair 18 Edward's syndrome Embryonic and Fetal Development Female Fetal edema Fetal karyotype Gynecology. Andrology. Obstetrics Humans Incidence Management. Prenatal diagnosis Mass Screening - methods Medical sciences Neck - diagnostic imaging Neck - embryology Nuchal translucency Pregnancy Pregnancy Trimester, Second Pregnancy. Fetus. Placenta Retrospective Studies Risk Factors Sensitivity and Specificity Time Factors Trisomy - diagnosis Trisomy 18 Ultrasonography, Prenatal - methods Ultrasound |
| title | Nuchal thickness evolution in trisomy 18 fetuses |
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