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Effects of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green in human septic shock
To evaluate the effect of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green (PDR) in patients with septic shock. A prospective clinical study in a university hospital intensive care unit. 20 patients in septic shock. Patients received iloprost infusion (...
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| Published in: | Intensive care medicine 2000-10, Vol.26 (10), p.1557-1560 |
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| container_issue | 10 |
| container_start_page | 1557 |
| container_title | Intensive care medicine |
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| creator | LEHMANN, Christian TAYMOORIAN, Kasra WAUER, Helmar KRAUSCH, Dietmar BIRNBAUM, Jürgen KOX, Wolfgang J |
| description | To evaluate the effect of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green (PDR) in patients with septic shock.
A prospective clinical study in a university hospital intensive care unit.
20 patients in septic shock. Patients received iloprost infusion (1 ng/kg per minute) for 24 h.
PDR was determined by a femoral arterial fiberoptic catheter before, 1, 6, and 24 h after start and 1 h after end of iloprost infusion. PDR increased significantly 24 h after start of iloprost infusion (baseline: 13.9 +/- 1.7% vs. 18.6 +/- 2.2%/min) and decreased 1 h after end of infusion (13.7 +/- 1.7%/min; p < 0.002). There was no change in pHi, cardiac index, mean arterial pressure, heart rate, central venous pressure, or intrathoracic blood volume index.
Administration of the stable prostacyclin analogue iloprost significantly increases PDR, indicating improvement in liver function. |
| doi_str_mv | 10.1007/s001340000662 |
| format | article |
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A prospective clinical study in a university hospital intensive care unit.
20 patients in septic shock. Patients received iloprost infusion (1 ng/kg per minute) for 24 h.
PDR was determined by a femoral arterial fiberoptic catheter before, 1, 6, and 24 h after start and 1 h after end of iloprost infusion. PDR increased significantly 24 h after start of iloprost infusion (baseline: 13.9 +/- 1.7% vs. 18.6 +/- 2.2%/min) and decreased 1 h after end of infusion (13.7 +/- 1.7%/min; p < 0.002). There was no change in pHi, cardiac index, mean arterial pressure, heart rate, central venous pressure, or intrathoracic blood volume index.
Administration of the stable prostacyclin analogue iloprost significantly increases PDR, indicating improvement in liver function.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s001340000662</identifier><identifier>PMID: 11126272</identifier><identifier>CODEN: ICMED9</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood ; Catheters ; Coloring Agents - pharmacokinetics ; Drug Monitoring - instrumentation ; Drug Monitoring - methods ; Dye Dilution Technique - instrumentation ; Emergency and intensive care: infection, septic shock ; Epoprostenol - analogs & derivatives ; Female ; Hemodynamics ; Humans ; Iloprost - pharmacology ; Iloprost - therapeutic use ; Indocyanine Green - pharmacokinetics ; Infusions, Intravenous ; Intensive care ; Intensive care medicine ; Leukocytes ; Liver ; Liver - metabolism ; Liver - physiopathology ; Liver Function Tests ; Male ; Medical sciences ; Metabolic Clearance Rate - drug effects ; Middle Aged ; Neutrophils ; Plasma ; Prospective Studies ; Sepsis ; Shock, Septic - drug therapy ; Shock, Septic - metabolism ; Shock, Septic - physiopathology ; Vasodilator Agents - pharmacology ; Vasodilator Agents - therapeutic use</subject><ispartof>Intensive care medicine, 2000-10, Vol.26 (10), p.1557-1560</ispartof><rights>2000 INIST-CNRS</rights><rights>Springer-Verlag 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-2e029666d8d99e33395afd34446f854780052f6ae534d475e6eaaedafc4d6fbd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1523780$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11126272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEHMANN, Christian</creatorcontrib><creatorcontrib>TAYMOORIAN, Kasra</creatorcontrib><creatorcontrib>WAUER, Helmar</creatorcontrib><creatorcontrib>KRAUSCH, Dietmar</creatorcontrib><creatorcontrib>BIRNBAUM, Jürgen</creatorcontrib><creatorcontrib>KOX, Wolfgang J</creatorcontrib><title>Effects of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green in human septic shock</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><description>To evaluate the effect of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green (PDR) in patients with septic shock.
A prospective clinical study in a university hospital intensive care unit.
20 patients in septic shock. Patients received iloprost infusion (1 ng/kg per minute) for 24 h.
PDR was determined by a femoral arterial fiberoptic catheter before, 1, 6, and 24 h after start and 1 h after end of iloprost infusion. PDR increased significantly 24 h after start of iloprost infusion (baseline: 13.9 +/- 1.7% vs. 18.6 +/- 2.2%/min) and decreased 1 h after end of infusion (13.7 +/- 1.7%/min; p < 0.002). There was no change in pHi, cardiac index, mean arterial pressure, heart rate, central venous pressure, or intrathoracic blood volume index.
Administration of the stable prostacyclin analogue iloprost significantly increases PDR, indicating improvement in liver function.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Catheters</subject><subject>Coloring Agents - pharmacokinetics</subject><subject>Drug Monitoring - instrumentation</subject><subject>Drug Monitoring - methods</subject><subject>Dye Dilution Technique - instrumentation</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Epoprostenol - analogs & derivatives</subject><subject>Female</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Iloprost - pharmacology</subject><subject>Iloprost - therapeutic use</subject><subject>Indocyanine Green - pharmacokinetics</subject><subject>Infusions, Intravenous</subject><subject>Intensive care</subject><subject>Intensive care medicine</subject><subject>Leukocytes</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver - physiopathology</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate - drug effects</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Sepsis</subject><subject>Shock, Septic - drug therapy</subject><subject>Shock, Septic - metabolism</subject><subject>Shock, Septic - physiopathology</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpd0c9LHDEUB_BQWupWPXotoZTeRvN7do4i9gcIXup5eJu8uNFMMp3MHPbmn25WF8TmkvDy4cH7PkLOODvnjLUXhTEuFavHGPGBrLiSouFCrj-SFZNKNMoocUS-lPJQZWs0_0yOOOfCiFasyNO192jnQrOn8xZpmWETkY5Tri-7szEkCglivl-QhphfPmhOL3iMUAagLhQYR4QJkkU6wYz7biG5bHeQQkJ6PyGmWqHbZYBEC45zsLRss308IZ88xIKnh_uY3P28_nv1u7m5_fXn6vKmsVLpuRHIRGeMcWvXdSil7DR4J5VSxq-1ateMaeENoJbKqVajQQB04K1yxm-cPCY_XvvWCf4tWOZ-CMVijJAwL6VvhWZct7zCb__Bh7xMNYLSd53UNWVmKmpeka15lAl9P05hgGnXc9bv99K_20v1Xw9Nl82A7k0fFlHB9wOAYiH6fZahvDktZJ1RPgOJ6ZX8</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>LEHMANN, Christian</creator><creator>TAYMOORIAN, Kasra</creator><creator>WAUER, Helmar</creator><creator>KRAUSCH, Dietmar</creator><creator>BIRNBAUM, Jürgen</creator><creator>KOX, Wolfgang J</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Effects of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green in human septic shock</title><author>LEHMANN, Christian ; TAYMOORIAN, Kasra ; WAUER, Helmar ; KRAUSCH, Dietmar ; BIRNBAUM, Jürgen ; KOX, Wolfgang J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-2e029666d8d99e33395afd34446f854780052f6ae534d475e6eaaedafc4d6fbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Catheters</topic><topic>Coloring Agents - pharmacokinetics</topic><topic>Drug Monitoring - instrumentation</topic><topic>Drug Monitoring - methods</topic><topic>Dye Dilution Technique - instrumentation</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Epoprostenol - analogs & derivatives</topic><topic>Female</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Iloprost - pharmacology</topic><topic>Iloprost - therapeutic use</topic><topic>Indocyanine Green - pharmacokinetics</topic><topic>Infusions, Intravenous</topic><topic>Intensive care</topic><topic>Intensive care medicine</topic><topic>Leukocytes</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Liver - physiopathology</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate - drug effects</topic><topic>Middle Aged</topic><topic>Neutrophils</topic><topic>Plasma</topic><topic>Prospective Studies</topic><topic>Sepsis</topic><topic>Shock, Septic - drug therapy</topic><topic>Shock, Septic - metabolism</topic><topic>Shock, Septic - physiopathology</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasodilator Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEHMANN, Christian</creatorcontrib><creatorcontrib>TAYMOORIAN, Kasra</creatorcontrib><creatorcontrib>WAUER, Helmar</creatorcontrib><creatorcontrib>KRAUSCH, Dietmar</creatorcontrib><creatorcontrib>BIRNBAUM, Jürgen</creatorcontrib><creatorcontrib>KOX, Wolfgang J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEHMANN, Christian</au><au>TAYMOORIAN, Kasra</au><au>WAUER, Helmar</au><au>KRAUSCH, Dietmar</au><au>BIRNBAUM, Jürgen</au><au>KOX, Wolfgang J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green in human septic shock</atitle><jtitle>Intensive care medicine</jtitle><addtitle>Intensive Care Med</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>26</volume><issue>10</issue><spage>1557</spage><epage>1560</epage><pages>1557-1560</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><coden>ICMED9</coden><abstract>To evaluate the effect of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green (PDR) in patients with septic shock.
A prospective clinical study in a university hospital intensive care unit.
20 patients in septic shock. Patients received iloprost infusion (1 ng/kg per minute) for 24 h.
PDR was determined by a femoral arterial fiberoptic catheter before, 1, 6, and 24 h after start and 1 h after end of iloprost infusion. PDR increased significantly 24 h after start of iloprost infusion (baseline: 13.9 +/- 1.7% vs. 18.6 +/- 2.2%/min) and decreased 1 h after end of infusion (13.7 +/- 1.7%/min; p < 0.002). There was no change in pHi, cardiac index, mean arterial pressure, heart rate, central venous pressure, or intrathoracic blood volume index.
Administration of the stable prostacyclin analogue iloprost significantly increases PDR, indicating improvement in liver function.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>11126272</pmid><doi>10.1007/s001340000662</doi><tpages>4</tpages></addata></record> |
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| ispartof | Intensive care medicine, 2000-10, Vol.26 (10), p.1557-1560 |
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| source | Springer Nature |
| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Catheters Coloring Agents - pharmacokinetics Drug Monitoring - instrumentation Drug Monitoring - methods Dye Dilution Technique - instrumentation Emergency and intensive care: infection, septic shock Epoprostenol - analogs & derivatives Female Hemodynamics Humans Iloprost - pharmacology Iloprost - therapeutic use Indocyanine Green - pharmacokinetics Infusions, Intravenous Intensive care Intensive care medicine Leukocytes Liver Liver - metabolism Liver - physiopathology Liver Function Tests Male Medical sciences Metabolic Clearance Rate - drug effects Middle Aged Neutrophils Plasma Prospective Studies Sepsis Shock, Septic - drug therapy Shock, Septic - metabolism Shock, Septic - physiopathology Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use |
| title | Effects of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green in human septic shock |
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