The Relationship Between Microvessel Density, the Expression of Vascular Endothelial Growth Factor (VEGF), and the Extension of Nasopharyngeal Carcinoma

• Published in: The Laryngoscope 2000-12, Vol.110 (12), p.2066-2069
• Main Authors: Guang-Wu, Huang, Sunagawa, Masanori, Jie-En, Li, Shimada, Seiji, Gang, Zeng, Tokeshi, Yoshihiro, Kosugi, Tadayoshi
• Format: Article
• Language: English
• Subjects: Adult; angiogenesis; Biological and medical sciences; Endothelial Growth Factors - metabolism; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Lymphokines - metabolism; Male; Medical sciences; Nasopharyngeal carcinoma; Nasopharyngeal Neoplasms - blood supply; Nasopharyngeal Neoplasms - metabolism; Nasopharyngeal Neoplasms - pathology; Nasopharynx - blood supply; Neoplasm Invasiveness; Neovascularization, Pathologic; Otorhinolaryngology. Stomatology; Prognosis; Protein Isoforms - metabolism; tumor metastasis; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; vascular endothelial growth factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors
• ISSN: 0023-852X; 1531-4995
• DOI: 10.1097/00005537-200012000-00017

Objective The present study was aimed at clarifying whether the microvessel density (MVD) and the e‐pression of vascular endothelial growth factor (VEGF) were related to the degree of local invasion and metastasis in nasopharyngeal carcinoma (NPC). Study Design We measured the MVD and examined whether VEGF was expressed in NPC tissue using histological study combined with immunohistochemistry. Methods MVD and VEGF expression was measured in 73 specimens of NPC, 15 benign tumors of nasopharyngeal region, and 20 nasopharyngeal tissue without tumor. MVD and VEGF expression in NPC was compared between a metastasis group (49 specimens) and a non‐metastasis group (24 specimens). Results Both MVD and VEGF expression were markedly increased in NPC tissue as compared with those in benign tumors of nasopharyngeal region. Both MVD and VEGF expression in NPC tissue with metastasis were statistically significantly increased as compared with those in NPC without metastasis. Therefore, the invasion and metastasis of NPC cells were closely related to MVD and the expression of VEGF in NPC tissue. Conclusion The metastatic potency of NPC tissue and the prognosis of the patients with NPC can be estimated by measuring MVD and the expression of VEGF in NPC tissue. Drugs that have inhibitory actions on angiogenesis could be useful to prevent metastasis of NPC cells in the patients.