Immunohistochemical Absence of CD21 Membrane Receptor in Nasopharyngeal Carcinoma Cells Infected by Epstein-Barr Virus in Spanish Patients

Objectives/Hypothesis The aim of this study was to analyze the relevance of the CD21 membrane receptor in nasopharyngeal carcinoma (NPC). CD21 is implicated in the introduction of the Epstein‐Barr virus (EBV) genome into epithelial cells and B lymphocytes. Study Design Immunohistochemical analysis o...

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Bibliographic Details
Published in:The Laryngoscope 2000-12, Vol.110 (12), p.2081-2084
Main Authors: Burgos, Javier S., Vera-Sempere, Francisco J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - virology
Ent. Stomatology
Epstein-Barr virus
Epstein-Barr Virus Infections - metabolism
Female
Humans
In Situ Hybridization
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
nasopharyngeal carcinoma
Nasopharyngeal Neoplasms - metabolism
Nasopharyngeal Neoplasms - virology
non-isotopic in situ hybridization
Otorhinolaryngology. Stomatology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
PCR
Receptors, Complement 3d - metabolism
Spain
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Objectives/Hypothesis The aim of this study was to analyze the relevance of the CD21 membrane receptor in nasopharyngeal carcinoma (NPC). CD21 is implicated in the introduction of the Epstein‐Barr virus (EBV) genome into epithelial cells and B lymphocytes. Study Design Immunohistochemical analysis of CD21 in NPC. Methods Paraffin‐embedded samples of NPC of different histological types with demonstrated presence of EBV were analyzed for CD21 expression using immunohistochemistry. Results We detected EBV by non‐isotopic in situ hybridization (NISH) and nested polymerase chain reaction (PCR) in 100% of samples, regardless of histological type, supporting the previous view that all the types of NPC are variants of an EBV‐associated malignancy. CD21 was not detected in NPC, and this absence was a typical feature in our data group. Conclusions The loss of the CD21 membrane receptor could be one of the immunophenotypical changes of the neoplastic cells that occur in the evolution of the NPC malignancy.
ISSN:0023-852X
1531-4995
DOI:10.1097/00005537-200012000-00020