A Statistical Method for the Comparison of a Discrete Diagnostic Test with Several Continuous Diagnostic Tests

In this paper we study a statistic that is suitable for comparing a discrete diagnostic marker to one or more continuous diagnostic markers. Test procedures and confidence intervals are based on asymptotic normality. The statistic is applicable for correlated data in which all the markers are obtain...

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Bibliographic Details
Published in:Biometrics 1991-09, Vol.47 (3), p.907-919
Main Authors: Beam, Craig A., Wieand, H. Samuel
Format: Article
Language:English
Subjects:
Analysis of Variance
Applied statistics
Biological and medical sciences
Biometrics
Biometry
Blood
Carcinoembryonic Antigen - analysis
Colonic Neoplasms - pathology
Confidence interval
Consistent estimators
Diagnosis
Estimators
Female
Fundamental and applied biological sciences. Psychology
Gastrointestinal Neoplasms - diagnosis
Gastrointestinal Neoplasms - prevention & control
General aspects
Hematocrit
Humans
Intestinal Obstruction - surgery
Mass Screening - methods
Mathematics
Medical diagnostic tests
Monte Carlo Method
Occult Blood
Ovarian Neoplasms - complications
Palliative Care
Ploidies
Prognosis
Rectal Neoplasms - pathology
Separators
Statistical variance
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Description
Summary:In this paper we study a statistic that is suitable for comparing a discrete diagnostic marker to one or more continuous diagnostic markers. Test procedures and confidence intervals are based on asymptotic normality. The statistic is applicable for correlated data in which all the markers are obtained for each subject. The statistic was studied for use in comparing two markers for rectal bleeding. Examples for this application and two more general applications are presented.
ISSN:0006-341X
1541-0420
DOI:10.2307/2532648