The Role of the Pro-Apoptotic Bcl-2 Family Member Bim in Physiological Cell Death

: Apoptosis, an evolutionarily conserved process for killing unwanted cells in multicellular organisms, is essential for normal development, tissue homeostasis and as a defense against pathogens. The control of apoptosis is of considerable importance for clinical medicine, as its deregulation can le...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2000-01, Vol.926 (1), p.83-89
Main Authors: BOUILLET, PHILIPPE, HUANG, DAVID C.S., O'REILLY, LORRAINE A., PUTHALAKATH, HAMSA, O'CONNOR, LIAM, CORY, SUZANNE, ADAMS, JERRY M., STRASSER, ANDREAS
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - physiology
Apoptosis Regulatory Proteins
Autoimmunity
Bcl-2 family
Bcl-2-Like Protein 11
Bim
Caenorhabditis elegans Proteins
Carrier Proteins - genetics
Carrier Proteins - metabolism
Embryonic and Fetal Development
Humans
Leukocytes - physiology
Membrane Proteins
Mice
Mice, Transgenic
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2 - physiology
Repressor Proteins - metabolism
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Summary:: Apoptosis, an evolutionarily conserved process for killing unwanted cells in multicellular organisms, is essential for normal development, tissue homeostasis and as a defense against pathogens. The control of apoptosis is of considerable importance for clinical medicine, as its deregulation can lead to cancer, autoimmunity or degenerative diseases. We have disrupted the Bim gene in the mouse and demonstrated that it plays a major and non‐redundant role in embryogenesis, in the control of hematopoietic cell death, and as a barrier against autoimmunity.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2000.tb05601.x