Phenylpropenamide derivatives as inhibitors of Hepatitis B virus replication

A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in cell culture has been discovered. A series of substituted analogues of phenylpropenamide 6 has been prepared and evaluated in the HepAD38 cellular assay. Structure–activity relationships of this series ar...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2000-12, Vol.10 (23), p.2687-2690
Main Authors: Perni, Robert B, Conway, Samuel C, Ladner, Stephanie K, Zaifert, Katie, Otto, Michael J, King, Robert W
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Benzamides - chemistry
Benzamides - pharmacology
Biological and medical sciences
Cell Line
Hepatitis B virus - drug effects
Hepatitis B virus - physiology
Medical sciences
Pharmacology. Drug treatments
Piperidines - chemistry
Piperidines - pharmacology
Structure-Activity Relationship
Virus Replication - drug effects
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Summary:A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in cell culture has been discovered. A series of substituted analogues of phenylpropenamide 6 has been prepared and evaluated in the HepAD38 cellular assay. Structure–activity relationships of this series are discussed.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00544-8