Clinical drug-resistant nodular sclerosing Hodgkin's lymphoma is associated with decreased bcl-2 expression in the surrounding lymphocytes and with increased bcl-2 expression in the Reed-Sternberg cells

Identification of patients with Hodgkin's lymphoma who are primary refractory to chemotherapy will have great impact on treatment planning. Several studies have indicated that up‐regulation of the bcl‐2 proto‐oncogene expression in non‐Hodgkin's lymphoma can cause resistance to chemotherap...

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Bibliographic Details
Published in:Histopathology 2000-11, Vol.37 (5), p.420-426
Main Authors: Van Spronsen, D J, Peh, S C, Vrints, L W, Van Imhoff, G W, Poppema, S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antigens, Nuclear
apoptosis
bcl-2
bcl-2-Associated X Protein
Biological and medical sciences
Cell Count
Drug Resistance, Neoplasm
Female
Hematologic and hematopoietic diseases
Hodgkin Disease - metabolism
Hodgkin Disease - mortality
Hodgkin Disease - pathology
Hodgkin Disease - therapy
Hodgkin's lymphoma
Humans
Immunohistochemistry
Ki-67 Antigen
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphocytes - metabolism
Male
Medical sciences
multidrug-resistance
Neoplasm Staging
Nuclear Proteins - metabolism
prognosis
proliferation index
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-bcl-2 - metabolism
Reed-Sternberg Cells - metabolism
Remission Induction
Sclerosis - pathology
Survival Rate
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Summary:Identification of patients with Hodgkin's lymphoma who are primary refractory to chemotherapy will have great impact on treatment planning. Several studies have indicated that up‐regulation of the bcl‐2 proto‐oncogene expression in non‐Hodgkin's lymphoma can cause resistance to chemotherapeutic drugs. For this reason we investigated the relationship between expression of bcl‐2, the pro‐apoptotic protein Bax and MIB‐1 with clinical drug‐resistance in Hodgkin's lymphoma Methods and results:  Seven patients with nodular sclerosis Hodgkin's lymphoma under 40 years of age, who failed to achieve complete remission upon primary chemotherapy and 10 matched patients who did achieve complete response were selected from the Eindhoven Cancer Registry. Tissue sections from both groups of patients were stained for bcl‐2, Bax and MIB‐1. In the non‐responding patients Reed–Sternberg cells expressed bcl‐2 more frequently using a cut‐off point of
ISSN:0309-0167
1365-2559
DOI:10.1046/j.1365-2559.2000.01010.x