The role of insulin-related substance in Hodgkin's disease

An insulin-related growth-promoting substance was detected in the serum of a patient with Hodgkin's disease who suffered from severe hypoglycaemia, as well as in the supernatant of homogenized spleen tissue of the same patient. Low concentrations of this substance enhanced DNA synthesis of shor...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1991-01, Vol.117 (6), p.615-619
Main Authors: CABRIJAN, T, LEVANAT, S, GRAZLO, S, PAVELIC, K, PEKIC, B, PAVELIC, J, SPAVENTI, R, FRAHM, H, ZJACIC-ROTKVIC, V, GOLDONI, V, VRBANEC, D, MISJAK, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Glucose
Cell Division - physiology
Chromatography, Ion Exchange
DNA - biosynthesis
Endothelial Growth Factors - physiology
Epidermal Growth Factor - physiology
Fibroblast Growth Factors - physiology
Hematologic and hematopoietic diseases
Hodgkin Disease - metabolism
Humans
Insulin - metabolism
Insulin-Like Growth Factor I - physiology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Platelet-Derived Growth Factor - physiology
Somatomedins - biosynthesis
Somatomedins - isolation & purification
Tumor Cells, Cultured
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Summary:An insulin-related growth-promoting substance was detected in the serum of a patient with Hodgkin's disease who suffered from severe hypoglycaemia, as well as in the supernatant of homogenized spleen tissue of the same patient. Low concentrations of this substance enhanced DNA synthesis of short-term-cultured spleen tumour cells obtained from the same patient, while the addition of anti-insulin antiserum interfered with that effect. Moreover, the preincubation of this insulin-related substance with the anti-insulin antiserum abrogated its stimulatory effect on tumour cell proliferation. Both insulin and the insulin-related substance bound to patients splenocytes to a similar extent. The data suggest that the insulin-related substance, found in this particular case of Hodgkin's disease, plays a role in tumour progression by an autocrine mechanism.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF01613298