Allogeneic Haemopoietic Stem Cell Transplantation for Multiple Myeloma or Plasma Cell Leukaemia Using Fractionated Total Body Radiation and High-dose Melphalan Conditioning

We have evaluated the outcome of allogeneic haemopoietic stem cell transplantation for multiple myeloma using a conditioning regimen comprising fractionated total body irradiation and high-dose melphalan (110 mg/m2). The study comprised 25 patients (median age 49 years) who had been transplanted by...

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Bibliographic Details
Published in:Acta oncologica 2000, Vol.39 (7), p.837-841
Main Author: Nigel Russell, Eric Bessell, Claire Stainer, Andrew Haynes, Emma Das-Gupta, Jenny Byrne
Format: Article
Language:English
Subjects:
Adult
Age Factors
Age of Onset
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antineoplastic Agents - administration & dosage
Biological and medical sciences
Bone marrow, stem cells transplantation. Graft versus host reaction
Disease-Free Survival
Female
Granulocyte Colony-Stimulating Factor - administration & dosage
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cell Transplantation
Humans
Male
Medical sciences
Melphalan - administration & dosage
Middle Aged
Multiple Myeloma - therapy
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation Conditioning
Transplantation, Homologous
Treatment Outcome
Whole-Body Irradiation
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Summary:We have evaluated the outcome of allogeneic haemopoietic stem cell transplantation for multiple myeloma using a conditioning regimen comprising fractionated total body irradiation and high-dose melphalan (110 mg/m2). The study comprised 25 patients (median age 49 years) who had been transplanted by either bone marrow (n = 13) or G-CSF mobilized peripheral blood stem cells (n = 12). Overall transplant-related mortality was 30% but was lower for patients
ISSN:0284-186X
1651-226X
DOI:10.1080/028418600750063596