The Rat as an Experimental Model for Sleep Neurophysiology

The aim of this study was to develop a sleep-wake recording system for rats that would yield results more comparable to those obtained from cats than those that are usually reported. For 18 male Sprague-Dawley rats, the authors combined measures of cortical and hippocampal electroencephalogram (EEG)...

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Bibliographic Details
Published in:Behavioral neuroscience 2000-12, Vol.114 (6), p.1239-1244
Main Authors: Datta, Subimal, Hobson, J. Allan
Format: Article
Language:English
Subjects:
Anatomy & physiology
Animal
Animal Models
Animals
Behavioral sciences
Biological and medical sciences
Brain Mapping
Cats
Cerebral Cortex
Cerebral Cortex - physiology
Electroencephalography
Electromyography
Electrophysiology
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus - physiology
Laboratory animals
Male
Models, Neurological
Neurology
Polysomnography
Pons - physiology
Rats
Rats, Sprague-Dawley
REM Sleep
Rodents
Sleep disorders
Sleep Stages - physiology
Sleep, REM - physiology
Sleep. Vigilance
Space life sciences
Vertebrates: nervous system and sense organs
Wakefulness - physiology
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Summary:The aim of this study was to develop a sleep-wake recording system for rats that would yield results more comparable to those obtained from cats than those that are usually reported. For 18 male Sprague-Dawley rats, the authors combined measures of cortical and hippocampal electroencephalogram (EEG) and neck muscle electromyogram with the electrooculogram and pontine EEG, so that the behavioral states could be identified with greater confidence with the use of polygraphic criteria developed in the cat and so that the distinctive phasic events of REM sleep could be more easily studied in the rat. The results suggest that for many neurophysiological studies, the rat is a suitable alternative to the cat.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.114.6.1239