Recurrent cholestasis and hypereosinophilia in a young female

A 22-year-old female presented, in December 199B, with asthenia, itching and hypereosinophilia. In January 1997, due to the same clinical picture, the patient had inappropriately been diagnosed elsewhere to have an “idiopathic eosinophilic syndrome” and complete remission was obtained after short-te...

Full description

Saved in:
Bibliographic Details
Published in:Digestive and liver disease 2000-10, Vol.32 (7), p.630-633
Main Authors: Pometta, R., Callea, F., Mangano, M., Zuccoli, E., Conte, D.
Format: Article
Language:English
Subjects:
Adult
Cholangitis, Sclerosing - blood
Cholangitis, Sclerosing - diagnosis
Cholangitis, Sclerosing - pathology
cholestasis
Cholestasis - blood
Cholestasis - diagnosis
Diagnostic Errors
eosinophilia
Eosinophilia - diagnosis
Eosinophilia - pathology
Female
Humans
Hypereosinophilic Syndrome - diagnosis
Liver Function Tests
Recurrence
sclerosing cholangitis
Transaminases - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 22-year-old female presented, in December 199B, with asthenia, itching and hypereosinophilia. In January 1997, due to the same clinical picture, the patient had inappropriately been diagnosed elsewhere to have an “idiopathic eosinophilic syndrome” and complete remission was obtained after short-term steroid treatment. Upon admission, physical examination was negative and blood tests revealed absolute eosinophilia (42%, i.e., 3800 of 9600 white blood cells), aspartate aminotransferase 4 × upper limits of normal, alanine aminotransferase 5 × upper limits of normal and alkaline phosphatase 2 × upper limits of normal. Both liver biopsy and endoscopic retrograde cholangiopancreatography findings were totally consistent with primary sclerosing cholangitis, while all known causes of hypereosinophilia and alteration in liver function tests were carefully excluded. The clinical course was characterized by complete clinical and biochemical normalization in absence of any treatment and further follow-up was completely negative.
ISSN:1590-8658
1878-3562
DOI:10.1016/S1590-8658(00)80849-X