Comparison of Tc-99m Depreotide and In-111 Octreotide in Recurrent Meningioma

PURPOSE For more than a decade, In-111 octreotide has been known to accumulate in meningiomas as a result of the expression of subtype 2 somatostatin receptors. Improved imaging characteristics can be expected with the recently developed radiotracer Tc-99m depreotide, which also binds to subtype 2 s...

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Published in:Clinical nuclear medicine 2002-11, Vol.27 (11), p.781-784
Main Authors: HELLWIG, DIRK, SAMNICK, SAMUEL, REIF, JOHANNES, ROMEIKE, BERND F.M, REITH, WOLFGANG, MORINGLANE, JEAN R, KIRSCH, CARL-MARTIN
Format: Article
Language:English
Subjects:
Biological and medical sciences
Eye Neoplasms - diagnostic imaging
Eye Neoplasms - surgery
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Meningeal Neoplasms - diagnostic imaging
Meningeal Neoplasms - surgery
Meningioma - diagnostic imaging
Meningioma - surgery
Middle Aged
Neoplasm Recurrence, Local - diagnostic imaging
Nervous system
Neurology
Octreotide - analogs & derivatives
Organotechnetium Compounds
Radionuclide Imaging
Radionuclide investigations
Radiopharmaceuticals
Somatostatin - analogs & derivatives
Tumors of the nervous system. Phacomatoses
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Summary:PURPOSE For more than a decade, In-111 octreotide has been known to accumulate in meningiomas as a result of the expression of subtype 2 somatostatin receptors. Improved imaging characteristics can be expected with the recently developed radiotracer Tc-99m depreotide, which also binds to subtype 2 somatostatin receptors. MATERIALS AND METHODS The authors examined a patient with intraorbital and extracranial recurrent meningioma using SPECT with Tc-99m depreotide and In-111 octreotide. The tumor-to-background ratios in the lesions were compared and the findings were correlated with histopathologic findings. RESULTS Although the tumor-to-background ratios were higher for the In-111–labeled tracer in the largest tumor lesion (5.7 versus 3.3), SPECT with the Tc-99m–labeled compound showed a proved second site of recurrence as a result of the better resolution that can be achieved with that isotope. CONCLUSIONS SPECT with Tc-99m depreotide appears to be clinically useful for detecting recurrent meningiomas with higher resolution and may outperform In-111 octreotide imaging in patients with meningiomas.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-200211000-00005