Brain stem GABA receptor functional regulation during rat liver cell proliferation

GABAergic alterations in brain stem during compensatory hyperplasia after partial hepatectomy (PH), lead nitrate (LN)-induced direct hyperplasia, and N-nitrosodiethylamine (NDEA)-induced neoplasia in liver were investigated. GABA content decreased in brain stem of PH- and NDEA-treated rats while it...

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Bibliographic Details
Published in:Neurochemical research 2002-09, Vol.27 (9), p.905-910
Main Authors: BIJU, Mangatt P, PYROJA, Sulaiman, RAJESHKUMAR, Neelimmathara V, PAULOSE, Cheramadathikudyil S
Format: Article
Language:English
Subjects:
Animals
Baclofen - metabolism
Biological and medical sciences
Brain Stem - metabolism
Cell Division - physiology
Chromatography, High Pressure Liquid
Fundamental and applied biological sciences. Psychology
Liver - cytology
Male
Protein Binding
Radioligand Assay
Rats
Rats, Wistar
Receptors, GABA - metabolism
Receptors, GABA - physiology
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Summary:GABAergic alterations in brain stem during compensatory hyperplasia after partial hepatectomy (PH), lead nitrate (LN)-induced direct hyperplasia, and N-nitrosodiethylamine (NDEA)-induced neoplasia in liver were investigated. GABA content decreased in brain stem of PH- and NDEA-treated rats while it increased in LN-treated rats. GABA(A) receptor number and affinity in brain stem membrane preparations of rats showed a significant decrease in PH- and NDEA-treated rats. The GABA(B) receptor number increased in PH- and NDEA-treated rats with an increase in affinity. The results of the present study indicate that liver cell proliferation is influencing the brain stem GABAergic neurotransmission and these changes regulate the hepatic proliferation through the sympathetic stimulation.
ISSN:0364-3190
1573-6903
DOI:10.1023/a:1020391514995