Role of mitochondrial dysfunction in Alzheimer's disease

Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this...

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Bibliographic Details
Published in:Journal of neuroscience research 2002-11, Vol.70 (3), p.357-360
Main Authors: Castellani, Rudy, Hirai, Keisuke, Aliev, Gjumrakch, Drew, Kelly L., Nunomura, Akihiko, Takeda, Atsushi, Cash, Adam D., Obrenovich, Mark E., Perry, George, Smith, Mark A.
Format: Article
Language:English
Subjects:
Alzheimer Disease - etiology
Alzheimer Disease - metabolism
Alzheimer Disease - physiopathology
Alzheimer's disease
Animals
Brain - metabolism
Brain - pathology
Brain - physiopathology
Cytochromes - deficiency
Cytochromes - genetics
DNA, Mitochondrial - genetics
Energy Metabolism - physiology
Humans
mitochondria
Mitochondria - metabolism
Mitochondria - pathology
Mitochondrial Diseases - complications
Mitochondrial Diseases - metabolism
Mitochondrial Diseases - physiopathology
Mutation - genetics
Neurons - metabolism
Neurons - pathology
oxidative stress
Oxidative Stress - physiology
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Summary:Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease. © 2002 Wiley‐Liss, Inc.
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.10389