Genetic Factors in the Genesis of Alzheimer's Disease

: At least four different genes have been identified that are associated with inherited susceptibility to Alzheimer's disease. Some of the genes are highly penetrant (PS1, PS2, bAPP); the other, APOE, is a weaker susceptibility factor. Several additional genes are suspected to exist but have no...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2000-01, Vol.924 (1), p.1-7
Main Author: ST GEORGE-HYSLOP, P. H.
Format: Article
Language:English
Subjects:
AD susceptibility genes
Alzheimer Disease - etiology
Alzheimer Disease - genetics
Amyloid-beta hypothesis
APOE
Brain Chemistry - genetics
Familial AD
Genetic Predisposition to Disease
Humans
Inheritance of AD
Penetrance
Tau protein mutations
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Summary:: At least four different genes have been identified that are associated with inherited susceptibility to Alzheimer's disease. Some of the genes are highly penetrant (PS1, PS2, bAPP); the other, APOE, is a weaker susceptibility factor. Several additional genes are suspected to exist but have not yet been cloned.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2000.tb05552.x