Conditioned and Unconditioned Behavioral-Cognitive Effects of a Dopamine Antagonist in Rats

Many drugs need to be taken multiple times to achieve a therapeutic effect. Researchers have identified several mechanisms to account for the slow onset of drug action, including drug accumulation and structural changes induced by drugs. This article provides an example of a new mechanism to account...

Full description

Saved in:
Bibliographic Details
Published in:Behavioral neuroscience 2000-12, Vol.114 (6), p.1251-1255
Main Authors: Ohyama, Tatsuya, Horvitz, Jon C, Drew, Michael R, Gibbon, John, Malapani, Chara, Balsam, Peter D
Format: Article
Language:English
Subjects:
Animal
Animals
Association Learning - drug effects
Behavior
Behavioral psychophysiology
Behavioral sciences
Biological and medical sciences
Cognition & reasoning
Cognitive Processes
Conditioned Responses
Conditioning, Classical - drug effects
Dopamine Antagonists - pharmacology
Drug Administration Schedule
Drugs
Extinction, Psychological - drug effects
Fundamental and applied biological sciences. Psychology
Hypothesis Testing
Male
Mental Recall - drug effects
Neurology
Neurotransmission and behavior
Pimozide
Pimozide - pharmacology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopharmacology
Rats
Reinforcement Schedule
Rodents
Time Perception - drug effects
Unconditioned Responses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Many drugs need to be taken multiple times to achieve a therapeutic effect. Researchers have identified several mechanisms to account for the slow onset of drug action, including drug accumulation and structural changes induced by drugs. This article provides an example of a new mechanism to account for this change in drug action. Stimuli that accompany drug administration may come to evoke conditioned responses (CRs), and these CRs may be the basis for changes in drug efficacy. Specifically, this research shows that a dopamine antagonist, pimozide, changes response rates through the direct action of the drug but changes time perception through the CRs elicited by drug administration.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.114.6.1251