The simultaneous presentation of sarcoidosis and common variable immune deficiency

Sarcoidosis and common variable immune deficiency can rarely present simultaneously in the same individual. We describe a child who presented with both disorders. The diagnosis of sarcoidosis was delayed because of the atypical appearances of the liver biopsy. She failed to respond to intravenous im...

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Bibliographic Details
Published in:Pathology 2000-11, Vol.32 (4), p.280-282
Main Authors: AMERATUNGA, Rohan, BECROFT, David M. O, HUNTER, Warwick
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child, Preschool
Common Variable Immunodeficiency - complications
Common Variable Immunodeficiency - drug therapy
Common Variable Immunodeficiency - pathology
Drug Therapy, Combination
Fatal Outcome
Female
Giant Cells - pathology
Granuloma - pathology
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulins, Intravenous - therapeutic use
Immunopathology
Immunosuppressive Agents - therapeutic use
Liver - pathology
Lymph Nodes - pathology
Mediastinum
Medical sciences
Sarcoidosis - complications
Sarcoidosis - pathology
Sarcoidosis - therapy
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:Sarcoidosis and common variable immune deficiency can rarely present simultaneously in the same individual. We describe a child who presented with both disorders. The diagnosis of sarcoidosis was delayed because of the atypical appearances of the liver biopsy. She failed to respond to intravenous immunoglobulin but improved once cyclosporin and corticosteroids were added to her treatment regimen. It is important that the co-existence of both disorders is recognised so that treatment with a combination of intravenous immunoglobulin and immunosuppression can be in instituted to treat both the immune deficiency as well as the granulomatous disorder. As illustrated here, patients may fail to respond if either modality is used alone.
ISSN:0031-3025
1465-3931
DOI:10.1080/713688933