Evolution of drug-resistant Mycobacterium tuberculosis in the province of Castellón. 1992-1998

To determine the frequency of resistant Mycobacterium tuberculosis and the risk factors associated with resistance in the province of Castellón (Spain). This prospective study of M. tuberculosis sensitivity applied Canetti's method of proportions to all strains isolated in Castellón (n = 532) f...

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Bibliographic Details
Published in:Archivos de bronconeumología 2000-11, Vol.36 (10), p.551-556
Main Authors: Marín Royo, M, González Morán, F, Moreno Muñoz, R, Pardo Serrano, F, Prada Alfaro, P, Arnedo Pena, A, Aguar Benito, M C
Format: Article
Language:Spanish
Subjects:
Adolescent
Adult
Aged
Antitubercular Agents - pharmacology
Child
Child, Preschool
Drug Resistance, Multiple
Ethambutol - pharmacology
Female
Humans
Infant
Infant, Newborn
Isoniazid - pharmacology
Male
Microbial Sensitivity Tests
Middle Aged
Multivariate Analysis
Mycobacterium tuberculosis - drug effects
Prospective Studies
Rifampin - pharmacology
Risk Factors
Spain
Streptomycin - pharmacology
Tuberculosis, Multidrug-Resistant - microbiology
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Summary:To determine the frequency of resistant Mycobacterium tuberculosis and the risk factors associated with resistance in the province of Castellón (Spain). This prospective study of M. tuberculosis sensitivity applied Canetti's method of proportions to all strains isolated in Castellón (n = 532) from January 1992 through December 1998 (7 years); 461 cases were new. The overall frequency of resistant strains was 4.7% (25/532), of which 3.9% (18/461) were instances of primary resistance and 11.1% (7/63) were of secondary resistance. Three percent were resistant to isoniazid, 1.87% to rifampicin, 1.87% to streptomycin and 0.56% to ethambutol. Multiple drug resistance was found in 0.2% (1/461) of the new cases and 1.1% (6/532) overall. The presence of resistant M. tuberculosis was associated with a history of antituberculous treatment (OR = 3.14; p = 0.017) and the presence of one or more risk factors for tuberculosis (OR = 3.32; p = 0.066). The overall rates of resistant M. tuberculosis and multiple drug resistance are low in the province of Castellón; however resistance is associated with higher mortality such that controlling some preventable risk factors might reduce the frequency of resistance.
ISSN:0300-2896