The genetic epidemiology of psoriasis vulgaris in Chinese Han

Background The aim of this study was to explore the effects of genetic factors on the onset of psoriasis vulgaris and to develop a possible genetic model of psoriasis in Chinese Han. Methods Data for 1043 patients with psoriasis vulgaris were obtained by questionnaire. Complex segregation analysis a...

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Published in:International journal of dermatology 2002-10, Vol.41 (10), p.663-669
Main Authors: Zhang, Xuejun, Wang, Hongyan, Te-shao, Hsu, Yang, Sen, Chen, Shanyu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Age of Onset
Aged
Asian Continental Ancestry Group - genetics
Child
Child, Preschool
China - epidemiology
Female
Genetic Predisposition to Disease - genetics
Humans
Male
Middle Aged
Models, Genetic
Psoriasis - epidemiology
Psoriasis - genetics
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cited_by cdi_FETCH-LOGICAL-c4596-69cc89e77c0c43510f85bfe6e020078319cb1003b4fd7aa1d80129bfa618cd03
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container_issue 10
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container_title International journal of dermatology
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creator Zhang, Xuejun
Wang, Hongyan
Te-shao, Hsu
Yang, Sen
Chen, Shanyu
description Background The aim of this study was to explore the effects of genetic factors on the onset of psoriasis vulgaris and to develop a possible genetic model of psoriasis in Chinese Han. Methods Data for 1043 patients with psoriasis vulgaris were obtained by questionnaire. Complex segregation analysis and heritability were performed using Penrose's method, Falconer's method, and the epi info 6.0 and sage‐regtl programs. Results (1) For male and female patients, the peak ages of initial onset were 30–39 and 10–19 years, respectively, with the mean age of initial onset being 27.69 ± 12.32 years in males and 23.26 ± 12.56 years in females. (2) Of 1043 patients with psoriasis, 326 (31.26%) were reported to have a family history of psoriasis. The onset for males with a family history of psoriasis was earlier than that for those without a family history (P 
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Methods Data for 1043 patients with psoriasis vulgaris were obtained by questionnaire. Complex segregation analysis and heritability were performed using Penrose's method, Falconer's method, and the epi info 6.0 and sage‐regtl programs. Results (1) For male and female patients, the peak ages of initial onset were 30–39 and 10–19 years, respectively, with the mean age of initial onset being 27.69 ± 12.32 years in males and 23.26 ± 12.56 years in females. (2) Of 1043 patients with psoriasis, 326 (31.26%) were reported to have a family history of psoriasis. The onset for males with a family history of psoriasis was earlier than that for those without a family history (P &lt; 0.01). The morbidities of first‐degree relatives were 7.67% in patients with type I psoriasis and 5.27% in patients with type II (P &lt; 0.01), and those of second‐degree relatives were 1.04% in type I and 0.24% in type II (P &lt; 0.01). (3) The onset of psoriasis was earlier in females than in males in type I psoriasis (P &lt; 0.01), but this was not the case in type II (P &gt; 0.05). (4) The prevalence of psoriasis in first‐ and second‐degree relatives of the proband with psoriasis was 7.24 and 0.95%, respectively; higher than that in the general population (0.146%). (5) The heritability of psoriasis in first‐ and second‐degree relatives was 67.04 and 46.59%, respectively. The Mendelian, no‐major‐gene and environment model was rejected by complex segregation analysis. Conclusion Psoriasis vulgaris follows a pattern of polygenetic or multifactorial inheritance rather than single‐gene inheritance.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1046/j.1365-4362.2002.01596.x</identifier><identifier>PMID: 12390189</identifier><identifier>CODEN: IJDEBB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Age Distribution ; Age of Onset ; Aged ; Asian Continental Ancestry Group - genetics ; Child ; Child, Preschool ; China - epidemiology ; Female ; Genetic Predisposition to Disease - genetics ; Humans ; Male ; Middle Aged ; Models, Genetic ; Psoriasis - epidemiology ; Psoriasis - genetics</subject><ispartof>International journal of dermatology, 2002-10, Vol.41 (10), p.663-669</ispartof><rights>Copyright Blackwell Scientific Publications Ltd. Oct 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4596-69cc89e77c0c43510f85bfe6e020078319cb1003b4fd7aa1d80129bfa618cd03</citedby><cites>FETCH-LOGICAL-c4596-69cc89e77c0c43510f85bfe6e020078319cb1003b4fd7aa1d80129bfa618cd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12390189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xuejun</creatorcontrib><creatorcontrib>Wang, Hongyan</creatorcontrib><creatorcontrib>Te-shao, Hsu</creatorcontrib><creatorcontrib>Yang, Sen</creatorcontrib><creatorcontrib>Chen, Shanyu</creatorcontrib><title>The genetic epidemiology of psoriasis vulgaris in Chinese Han</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background The aim of this study was to explore the effects of genetic factors on the onset of psoriasis vulgaris and to develop a possible genetic model of psoriasis in Chinese Han. Methods Data for 1043 patients with psoriasis vulgaris were obtained by questionnaire. Complex segregation analysis and heritability were performed using Penrose's method, Falconer's method, and the epi info 6.0 and sage‐regtl programs. Results (1) For male and female patients, the peak ages of initial onset were 30–39 and 10–19 years, respectively, with the mean age of initial onset being 27.69 ± 12.32 years in males and 23.26 ± 12.56 years in females. (2) Of 1043 patients with psoriasis, 326 (31.26%) were reported to have a family history of psoriasis. The onset for males with a family history of psoriasis was earlier than that for those without a family history (P &lt; 0.01). The morbidities of first‐degree relatives were 7.67% in patients with type I psoriasis and 5.27% in patients with type II (P &lt; 0.01), and those of second‐degree relatives were 1.04% in type I and 0.24% in type II (P &lt; 0.01). (3) The onset of psoriasis was earlier in females than in males in type I psoriasis (P &lt; 0.01), but this was not the case in type II (P &gt; 0.05). (4) The prevalence of psoriasis in first‐ and second‐degree relatives of the proband with psoriasis was 7.24 and 0.95%, respectively; higher than that in the general population (0.146%). (5) The heritability of psoriasis in first‐ and second‐degree relatives was 67.04 and 46.59%, respectively. The Mendelian, no‐major‐gene and environment model was rejected by complex segregation analysis. Conclusion Psoriasis vulgaris follows a pattern of polygenetic or multifactorial inheritance rather than single‐gene inheritance.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China - epidemiology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Genetic</subject><subject>Psoriasis - epidemiology</subject><subject>Psoriasis - genetics</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqNkEFv0zAUx60JtJXBV5giDtwS_OzEjg87TC10QxNwqDTExXKcl85dmhS7gfbb45AKpJ04-Vnv9__r6UdIAjQDmov3mwy4KNKcC5YxSllGoVAiO5yR2bQQnL0gM0oBUkULdUFehbCJX84gPycXwLiiUKoZuV49YrLGDvfOJrhzNW5d3_brY9I3yS703pngQvJzaNfGx8F1yfzRdRgwuTXda_KyMW3AN6f3kqw-fljNb9P7L8u7-c19avN4VyqUtaVCKS21OS-ANmVRNSiQxuNlyUHZCijlVd7U0hioSwpMVY0RUNqa8kvybqrd-f7HgGGvty5YbFvTYT8ELVnBQMoRfPsM3PSD7-JpmjFWxlrBIlROkPV9CB4bvfNua_xRA9WjXr3Ro0U96tWjXv1Hrz7E6NWpf6i2WP8LnnxG4HoCfrkWj_9drO8-LcYp5tMp78IeD3_zxj9pIbks9MPnpX5YLL9_5fKbVvw3B9KWJA</recordid><startdate>200210</startdate><enddate>200210</enddate><creator>Zhang, Xuejun</creator><creator>Wang, Hongyan</creator><creator>Te-shao, Hsu</creator><creator>Yang, Sen</creator><creator>Chen, Shanyu</creator><general>Blackwell Science Ltd</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200210</creationdate><title>The genetic epidemiology of psoriasis vulgaris in Chinese Han</title><author>Zhang, Xuejun ; Wang, Hongyan ; Te-shao, Hsu ; Yang, Sen ; Chen, Shanyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4596-69cc89e77c0c43510f85bfe6e020078319cb1003b4fd7aa1d80129bfa618cd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>China - epidemiology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Genetic</topic><topic>Psoriasis - epidemiology</topic><topic>Psoriasis - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xuejun</creatorcontrib><creatorcontrib>Wang, Hongyan</creatorcontrib><creatorcontrib>Te-shao, Hsu</creatorcontrib><creatorcontrib>Yang, Sen</creatorcontrib><creatorcontrib>Chen, Shanyu</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xuejun</au><au>Wang, Hongyan</au><au>Te-shao, Hsu</au><au>Yang, Sen</au><au>Chen, Shanyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The genetic epidemiology of psoriasis vulgaris in Chinese Han</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2002-10</date><risdate>2002</risdate><volume>41</volume><issue>10</issue><spage>663</spage><epage>669</epage><pages>663-669</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><coden>IJDEBB</coden><abstract>Background The aim of this study was to explore the effects of genetic factors on the onset of psoriasis vulgaris and to develop a possible genetic model of psoriasis in Chinese Han. Methods Data for 1043 patients with psoriasis vulgaris were obtained by questionnaire. Complex segregation analysis and heritability were performed using Penrose's method, Falconer's method, and the epi info 6.0 and sage‐regtl programs. Results (1) For male and female patients, the peak ages of initial onset were 30–39 and 10–19 years, respectively, with the mean age of initial onset being 27.69 ± 12.32 years in males and 23.26 ± 12.56 years in females. (2) Of 1043 patients with psoriasis, 326 (31.26%) were reported to have a family history of psoriasis. The onset for males with a family history of psoriasis was earlier than that for those without a family history (P &lt; 0.01). The morbidities of first‐degree relatives were 7.67% in patients with type I psoriasis and 5.27% in patients with type II (P &lt; 0.01), and those of second‐degree relatives were 1.04% in type I and 0.24% in type II (P &lt; 0.01). (3) The onset of psoriasis was earlier in females than in males in type I psoriasis (P &lt; 0.01), but this was not the case in type II (P &gt; 0.05). (4) The prevalence of psoriasis in first‐ and second‐degree relatives of the proband with psoriasis was 7.24 and 0.95%, respectively; higher than that in the general population (0.146%). (5) The heritability of psoriasis in first‐ and second‐degree relatives was 67.04 and 46.59%, respectively. The Mendelian, no‐major‐gene and environment model was rejected by complex segregation analysis. Conclusion Psoriasis vulgaris follows a pattern of polygenetic or multifactorial inheritance rather than single‐gene inheritance.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12390189</pmid><doi>10.1046/j.1365-4362.2002.01596.x</doi><tpages>7</tpages></addata></record>
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subjects Adolescent
Adult
Age Distribution
Age of Onset
Aged
Asian Continental Ancestry Group - genetics
Child
Child, Preschool
China - epidemiology
Female
Genetic Predisposition to Disease - genetics
Humans
Male
Middle Aged
Models, Genetic
Psoriasis - epidemiology
Psoriasis - genetics
title The genetic epidemiology of psoriasis vulgaris in Chinese Han
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