Broad-Band Ion Accumulation with an Internal Source MALDI-FTICR-MS

A new method is described which allows a broad mass range of ions from multiple MALDI events to be accumulated in an FTICR analyzer cell prior to detection. Signal intensity and signal-to-noise ratio are observed to grow in direct proportion to the number of laser shots, providing a substantial impr...

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Published in:Analytical chemistry (Washington) 2000-12, Vol.72 (24), p.5886-5891
Main Authors: Mize, Todd H, Amster, I. Jonathan
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Cells
Chemistry
Fourier Analysis
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods
Ions
Lasers
Molecular Sequence Data
Proteins
Serum Albumin, Bovine - chemistry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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cited_by cdi_FETCH-LOGICAL-a404t-b119b57a38852fdfc1b1b6b4cb7f16970fdb52c3702597d8d682044cd525f75f3
cites cdi_FETCH-LOGICAL-a404t-b119b57a38852fdfc1b1b6b4cb7f16970fdb52c3702597d8d682044cd525f75f3
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creator Mize, Todd H
Amster, I. Jonathan
description A new method is described which allows a broad mass range of ions from multiple MALDI events to be accumulated in an FTICR analyzer cell prior to detection. Signal intensity and signal-to-noise ratio are observed to grow in direct proportion to the number of laser shots, providing a substantial improvement to the analysis of low-level samples compared to more commonly used signal-averaging methods. In addition, calibrant ions desorbed from a separate sample spot can be added to the analyzer cell after an analyte population has been accumulated, providing an internal mass standard without the necessity of mixing calibrant and analyte. This method provides excellent mass accuracy by eliminating mass errors due to space charge effects.
doi_str_mv 10.1021/ac000911r
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Cells
Chemistry
Fourier Analysis
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods
Ions
Lasers
Molecular Sequence Data
Proteins
Serum Albumin, Bovine - chemistry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
title Broad-Band Ion Accumulation with an Internal Source MALDI-FTICR-MS
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