Stimulation by Portal Insulin of Intestinal Glucose Absorption via Hepatoenteral Nerves and Prostaglandin E2 in the Isolated, Jointly Perfused Small Intestine and Liver of the Rat

: Insulin infused into the portal vein acutely enhanced intestinal glucose and galactose absorption via the sodium‐dependent glucose cotransporter‐1 in the isolated, jointly perfused small intestine and liver of the rat. Atropine and tetrodotoxin infused into the superior mesenteric artery completel...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2000, Vol.915 (1), p.111-116
Main Authors: STÜMPEL, FRANK, SCHOLTKA, BETTINA, JUNGERMANN, KURT
Format: Article
Language:English
Subjects:
Animals
Dinoprostone - metabolism
Enteric Nervous System - drug effects
Enteric Nervous System - physiology
Glucose - pharmacokinetics
Hypoglycemic Agents - pharmacology
Insulin - pharmacology
Intestine, Small - innervation
Intestine, Small - metabolism
Liver - blood supply
Liver - innervation
Liver - metabolism
Portal Vein - innervation
Portal Vein - physiology
Rats
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Summary:: Insulin infused into the portal vein acutely enhanced intestinal glucose and galactose absorption via the sodium‐dependent glucose cotransporter‐1 in the isolated, jointly perfused small intestine and liver of the rat. Atropine and tetrodotoxin infused into the superior mesenteric artery completely prevented the portal insulin‐dependent increase in intestinal glucose absorption, and carbachol caused an increase similar to that of portal insulin. Thus, a signal was transmitted against the bloodstream in a retrograde direction from the portal vein to the small intestine via hepatoenteral cholinergic nerves. The intracellular messenger in the enterocytes was cAMP, and the link between the muscarinic receptors, which do not increase cAMP concentrations, and adenylate cyclase was found to be prostaglandin E2.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2000.tb05232.x