Intestinal Cell Adhesion Molecules: Liver-Intestine Cadherin

: The cadherin superfamily comprises a large number of cell adhesion molecules, several of which are expressed in the gastrointestinal tract. LI‐cadherin represents a novel type of cadherin within the cadherin superfamily distinguished from other cadherins by structural and functional features descr...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2000-12, Vol.915 (1), p.136-143
Main Authors: GESSNER, REINHARD, TAUBER, RUDOLF
Format: Article
Language:English
Subjects:
Cadherins - genetics
Cadherins - metabolism
Enterocytes - chemistry
Enterocytes - metabolism
Goblet Cells - chemistry
Goblet Cells - metabolism
Humans
Intestinal Mucosa - chemistry
Intestinal Mucosa - cytology
Intestinal Mucosa - metabolism
Liver - chemistry
Liver - metabolism
Molecular Sequence Data
Sequence Homology, Amino Acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:: The cadherin superfamily comprises a large number of cell adhesion molecules, several of which are expressed in the gastrointestinal tract. LI‐cadherin represents a novel type of cadherin within the cadherin superfamily distinguished from other cadherins by structural and functional features described in this review. In the mouse and human, LI‐cadherin is selectively expressed on the basolateral surface of enterocytes and goblet cells in the small and large intestine, whereas in the rat this cadherin is additionally detectable in hepatocytes. LI‐cadherin is capable of mediating Ca2+‐dependent homophilic cell‐cell adhesion independent of interactions with the cytoskeleton, indicating that the adhesive function of this novel cadherin is complementary to that of E‐cadherin and desmosomal cadherins co expressed in the intestinal mucosa.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2000.tb05236.x