Genetics of atherosclerosis: the search for genes acting at the level of the vessel wall

Recent studies in mice have revealed genetic factors contributing to atherosclerosis that are independent of known risk factors. These factors appear to act locally, at the level of the vessel wall. In this review, we discuss these studies and summarize some of the cellular and molecular interaction...

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Bibliographic Details
Published in:Current atherosclerosis reports 2000-09, Vol.2 (5), p.380-389
Main Authors: Villa-Colinayo, V, Shi, W, Araujo, J, Lusis, A J
Format: Article
Language:English
Subjects:
Animals
Arteriosclerosis - genetics
Arteriosclerosis - pathology
Endothelium, Vascular - pathology
Endothelium, Vascular - physiology
Humans
Muscle, Smooth, Vascular - pathology
Muscle, Smooth, Vascular - physiology
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Summary:Recent studies in mice have revealed genetic factors contributing to atherosclerosis that are independent of known risk factors. These factors appear to act locally, at the level of the vessel wall. In this review, we discuss these studies and summarize some of the cellular and molecular interactions that may be involved. We also outline the approaches for the identification of such factors in humans.
ISSN:1523-3804
1534-6242
DOI:10.1007/s11883-000-0076-2