Impaired flow-mediated vasoactivity during post-prandial phase in young healthy men

• Published in: Atherosclerosis 2000-12, Vol.153 (2), p.397-402
• Main Authors: Marchesi, Simona, Lupattelli, Graziana, Schillaci, Giuseppe, Pirro, Matteo, Siepi, Donatella, Roscini, Anna Rita, Pasqualini, Leonella, Mannarino, Elmo
• Format: Article
• Language: English
• Subjects: Adult; Arteries; Arteriosclerosis - etiology; Arteriosclerosis - metabolism; Arteriosclerosis - physiopathology; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Brachial; Cardiology. Vascular system; Dietary Fats - administration & dosage; Endothelium; Endothelium, Vascular - physiology; Humans; Male; Medical sciences; Post-prandial lipemia; Postprandial Period - physiology; Triglyceridemia; Vasodilation; Vasodilation - physiology
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/S0021-9150(00)00415-9

Impaired flow-mediated vasodilation in large arteries is an expression of endothelial dysfunction and an established marker of early atherosclerosis. Post-prandial lipemia can induce an impairment of the endothelial function. The aim of our study was to evaluate the effects of post-prandial phase on flow-mediated vasodilation in a group of ten young (23±2 years) healthy men without cardiovascular risk factors, who underwent an oral fat-loading test. Flow-mediated vasodilation of the brachial artery and serum lipid profile were assessed under fasting conditions and 2, 4, 6 and 8 h after a high-fat meal. Triglycerides increased from 0.6±0.2 fasting to 1.1±0.5 and 1.3±0.6 mmol/l at the 2nd and 4th hour (both P