Parathyroid hormone‐related peptide producing cholangiocellular carcinoma with a marked psammoma formation

Humoral hypercalcemia caused by parathyroid hormone‐related peptide (PTHrP), associated with cholangiocellular carcinoma (CCC), has rarely been documented. There have been no reports of CCC associated with extensive calcification of the tumor with psammoma body formation. A 66‐year‐old man was admit...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2000-12, Vol.15 (12), p.1442-1446
Main Authors: Yamada, Shinwa, Sanefuji, Hayato, Morimoto, Hiroaki, Harada, Yuji, Mine, Shinichiro, Morimoto, Isao, Eto, Sumiya
Format: Article
Language:English
Subjects:
Aged
Angiography
Bile Duct Neoplasms - diagnostic imaging
Bile Duct Neoplasms - metabolism
Bile Duct Neoplasms - pathology
Bile Ducts, Intrahepatic
Biological and medical sciences
Calcinosis - diagnostic imaging
Calcinosis - pathology
Cholangiocarcinoma - diagnostic imaging
Cholangiocarcinoma - metabolism
Cholangiocarcinoma - pathology
cholangiocellular carcinoma
Digestive system
Humans
hypercalcemia
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Parathyroid Hormone-Related Protein
parathyroid hormone‐related peptide
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Protein Biosynthesis
psammoma body
Radiography, Abdominal
Tomography, X-Ray Computed
α‐fetoprotein
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Description
Summary:Humoral hypercalcemia caused by parathyroid hormone‐related peptide (PTHrP), associated with cholangiocellular carcinoma (CCC), has rarely been documented. There have been no reports of CCC associated with extensive calcification of the tumor with psammoma body formation. A 66‐year‐old man was admitted with a large calcified tumor in the liver detected on an abdominal X‐ray. An ultrasound‐guided fine needle biopsy specimen of the liver tumor showed evidence of adenocarcinoma. He had hypercalcemia with an elevated PTHrP level. The patient died because of disseminated intravascular coagulation and progressive hepatic failure. A postmortem examination revealed a large poorly differentiated CCC in the liver. Immunohistochemical examination showed the presence of PTHrP‐positive tumor cells. The calcified lesion consisted of a number of accumulated psammoma bodies. We present a case of PTHrP producing CCC with a marked psammoma formation.
ISSN:0815-9319
1440-1746
DOI:10.1046/j.1440-1746.2000.02222.x