Static cytometry identifies hyperdiploid childhood ALL

Hyperdiploid acute lymphoblastic leukemia of childhood has long been identified with a good prognosis. Identification of this subgroup before treatment commences would enable the most appropriate regimen to be selected. Static cytometry permits an assessment of the DNA content of morphologically sel...

Full description

Saved in:
Bibliographic Details
Published in:Cancer genetics and cytogenetics 2000-12, Vol.123 (2), p.123-127
Main Authors: van den Berghe, Janette A, Chen, Yueh-Chun, Zhang, Yili, Kueh, Yan-Koon, Lee, Szu-Hee
Format: Article
Language:English
Subjects:
Aneuploidy
Biological and medical sciences
Bone Marrow Cells - metabolism
Bone Marrow Cells - pathology
Child, Preschool
DNA, Neoplasm - genetics
DNA, Neoplasm - metabolism
Flow Cytometry - methods
Hematologic and hematopoietic diseases
Humans
Infant
Karyotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Retrospective Studies
Tropical medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hyperdiploid acute lymphoblastic leukemia of childhood has long been identified with a good prognosis. Identification of this subgroup before treatment commences would enable the most appropriate regimen to be selected. Static cytometry permits an assessment of the DNA content of morphologically selected interphase cells. The blast cells from seven retrospective and seven prospective cases were studied and the ploidy levels compared with the bone marrow karyotype. Static cytometry rapidly identified the hyperdiploid karyotype and, as it was performed specifically on blast cells, it also identified the percentage of these blast cells that were hyperdiploid.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(00)00312-5