Effect of resveratrol on intimal hyperplasia after endothelial denudation in an experimental rabbit model

The ability of resveratrol to inhibit vascular intimal thickening was tested in an experimental model in which endothelial denudation was performed in the normal rabbit iliac artery. Resveratrol (2∼4mg/kg/d) was administered intragastrically for 5 weeks beginning 1 week before denudation. At the hig...

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Bibliographic Details
Published in:Life sciences (1973) 2000-12, Vol.68 (2), p.153-163
Main Authors: Zou, Jiangang, Huang, Yuanzhu, Cao, Kejiang, Yang, Guoping, Yin, Hang, Len, Jing, Hsieh, Tze-chen, Wu, Joseph M.
Format: Article
Language:English
Subjects:
Animals
Antioxidants - therapeutic use
Cattle
Cells, Cultured
Denudation
Disease Models, Animal
Dose-Response Relationship, Drug
Endothelium, Vascular - surgery
Graft Occlusion, Vascular - drug therapy
Graft Occlusion, Vascular - prevention & control
Hyperplasia
Hyperplasia - pathology
Iliac Artery - drug effects
Iliac Artery - surgery
Male
Muscle, Smooth, Vascular - cytology
Muscle, Smooth, Vascular - drug effects
Rabbits
Restenosis
Resveratrol
Smooth muscle cell growth
Stilbenes - therapeutic use
Tunica Intima - drug effects
Tunica Intima - pathology
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Summary:The ability of resveratrol to inhibit vascular intimal thickening was tested in an experimental model in which endothelial denudation was performed in the normal rabbit iliac artery. Resveratrol (2∼4mg/kg/d) was administered intragastrically for 5 weeks beginning 1 week before denudation. At the higher concentration of resveratrol, the intimal hyperplasia of injured vascular wall was effectively inhibited; the intimal proliferation index also was significantly less than that in the untreated control group (0.28±0.07 vs 0.41±0.13, respectively, p
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(00)00925-5