Impact of oncogenes and tumor suppressor genes on deregulation of hemostasis and angiogenesis in cancer

We postulate that oncogenes and tumor suppressor genes may influence tumor angiogenesis not only directly (e.g. by upregulating vascular endothelial growth factor) but also through their impact on expression (and/or function) of tissue factor and other elements of the hemostatic system.

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Bibliographic Details
Published in:Cancer and metastasis reviews 2000, Vol.19 (1-2), p.93-96
Main Authors: Rak, J, Klement, G
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Cancer
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Genetics
Hemostasis - genetics
Hemostasis - physiology
Humans
Neoplasms - blood
Neoplasms - blood supply
Neoplasms - genetics
Neovascularization, Pathologic - genetics
Neovascularization, Pathologic - physiopathology
Oncogenes
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Description
Summary:We postulate that oncogenes and tumor suppressor genes may influence tumor angiogenesis not only directly (e.g. by upregulating vascular endothelial growth factor) but also through their impact on expression (and/or function) of tissue factor and other elements of the hemostatic system.
ISSN:0167-7659
1573-7233
DOI:10.1023/A:1026516920119