Clinical significance of abdominal scintigraphy using 99mTc-HMPAO-labelled leucocytes in patients with seronegative spondyloarthropathies

Abdominal scintigraphy shows silent gut inflammation in patients with spondyloarthropathies (Sp) without clinical evidence of gut inflammation. Abdominal scintigraphy images are different than those obtained in patients with ulcerative colitis or Crohn's disease and are not related to the anti-...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 2000-12, Vol.27 (12), p.1768-1773
Main Authors: FARTO, J. C, ALMOGUERA ARIAS, I, LOPEZ LONGO, F. J, GONZALEZ FERNANDEZ, C. M, MONTEAGUDO SAEZ, I, ORTEGA VALLE, A, BASCONES, M, PEREZ VAZQUEZ, J. M, CARRENO PEREZ, L
Format: Article
Language:English
Subjects:
Abdomen - diagnostic imaging
Adult
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biological and medical sciences
Digestion. Liver. Biliary tract. Spleen. Pancreas
Diseases of the osteoarticular system
Female
HLA-B27 Antigen - analysis
Humans
Image Interpretation, Computer-Assisted
Inflammatory joint diseases
Investigative techniques, diagnostic techniques (general aspects)
Leukocytes - diagnostic imaging
Male
Medical sciences
Middle Aged
Radionuclide Imaging
Radionuclide investigations
Radiopharmaceuticals
Spondylitis - diagnostic imaging
Spondylitis - drug therapy
Spondylitis - immunology
Technetium Tc 99m Exametazime
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Summary:Abdominal scintigraphy shows silent gut inflammation in patients with spondyloarthropathies (Sp) without clinical evidence of gut inflammation. Abdominal scintigraphy images are different than those obtained in patients with ulcerative colitis or Crohn's disease and are not related to the anti-inflammatory drugs administered. The aim of this study was to examine the clinical associations of findings on abdominal scintigraphy in patients with Sp. A total of 204 Sp patients (European Spondylarthropathy Study Group 1991 criteria) and 54 non-Sp controls receiving non-steroidal anti-inflammatory drugs were studied. Abdominal scintigraphy images were obtained at 30 and 120 min after injection of technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO)-labelled leucocytes. 99mTc-HMPAO-labelled leucocyte scans were positive in 104 Sp patients (50.9%) and in six non-Sp controls (2.9%) (P
ISSN:0340-6997
1619-7089
DOI:10.1007/s002590000393