Actin dynamics: Assembly and disassembly of actin networks

Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators Cdc42, PIP2 and profilin. Network disassembly and debranching appears to be linked to actin-bound ATP hydrolysis as fil...

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Bibliographic Details
Published in:Current biology 2000-12, Vol.10 (24), p.R891-R895
Main Authors: Wear, Martin A, Schafer, Dorothy A, Cooper, John A
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
Humans
Microfilament Proteins - metabolism
Models, Biological
Polymers - metabolism
Protein Structure, Tertiary
Proteins - genetics
Proteins - metabolism
Wiskott-Aldrich Syndrome Protein
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Summary:Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators Cdc42, PIP2 and profilin. Network disassembly and debranching appears to be linked to actin-bound ATP hydrolysis as filaments age.
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(00)00845-9