HLA class I and class II allele distribution in the Peruvian population

The distribution of HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 alleles in the Peruvian population was studied and compared with those of other populations in order to provide further information about their anthropological origin. Our data are consistent with the Mestizo character of this population. In terms o...

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Bibliographic Details
Published in:Tissue antigens 2000-12, Vol.56 (6), p.507-514
Main Authors: De Pablo, R., Beraún, Y., Nieto, A., Calzada, J.E., Rementería, M.C., Sanz, L., López-Nevot, M.A., Martín, J.
Format: Article
Language:English
Subjects:
African Continental Ancestry Group - genetics
Amerindians
Asian Continental Ancestry Group - genetics
Demography
European Continental Ancestry Group - genetics
Gene Frequency - immunology
Haplotypes - immunology
Histocompatibility Antigens Class I - genetics
Histocompatibility Antigens Class II - genetics
histocompatibility locus HLA
HLA
Humans
Indians, South American - genetics
Peru
Peruvian
Quechua
South America
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Summary:The distribution of HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 alleles in the Peruvian population was studied and compared with those of other populations in order to provide further information about their anthropological origin. Our data are consistent with the Mestizo character of this population. In terms of genetic distance Peruvians are closest to Bolivians, which is in agreement with the geographical location and the cultural and anthropological background of the two human groups. Several HLA‐B alleles originally described in genetically isolated Amerindian tribes are also present in the sample studied here. This fact and the reported finding of these alleles in several Amerindian groups suggests that they were present in the first wave of humans that populated South America (Paleoindians) before they split to give rise to the different South American tribes.
ISSN:0001-2815
1399-0039
DOI:10.1034/j.1399-0039.2000.560604.x