Genetic analyses of schizophrenia

Although evidence exists to support a heritable component to schizophrenia, few details are understood about the genetics of the disorder. Presently, molecular genetic techniques provide the most promise in uncovering the genetic mechanisms of disease. Candidate gene analyses and linkage studies hav...

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Bibliographic Details
Published in:Current psychiatry reports 2000-04, Vol.2 (2), p.137-142
Main Authors: Pato, C N, Schindler, K M, Pato, M T
Format: Article
Language:English
Subjects:
Chromosome Aberrations - genetics
Chromosome Disorders
Gene Expression
Genetic Linkage
Genetic Predisposition to Disease
Humans
Psychiatry
Schizophrenia
Schizophrenia - genetics
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Summary:Although evidence exists to support a heritable component to schizophrenia, few details are understood about the genetics of the disorder. Presently, molecular genetic techniques provide the most promise in uncovering the genetic mechanisms of disease. Candidate gene analyses and linkage studies have opened some prospective avenues for exploration. Clearer findings from these studies many be hidden by the syndromic nature of schizophrenia. The study of more genetically homogenous populations and symptom-based phenotypic subtypes may help to make this genetic data more revealing. This review highlights some of the latest progress and findings in the molecular genetic analyses of schizophrenia, including both candidate gene analyses and genome scan studies.
ISSN:1523-3812
1535-1645
DOI:10.1007/s11920-000-0058-7