Effects of cold stress on glutathione and related enzymes in rat erythrocytes

Effects of acute and chronic cold stress on glutathione and related enzymes in rat erythrocytes were investigated. Blood from both cold-acclimated (CA) and cold-adapted (CG) rats had significantly lower concentrations of glutathione than blood from control animals. Superoxide dismutase activity was...

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Bibliographic Details
Published in:International journal of biometeorology 1991-06, Vol.35 (2), p.111-113
Main Authors: OHNO, H, KONDO, T, FUJIWARA, Y, TAGAMI, S, KUROSHIMA, A, KAWAKAMI, Y
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cold Climate - adverse effects
Erythrocytes - metabolism
Fundamental and applied biological sciences. Psychology
Glutathione - blood
Male
Rats
Rats, Inbred Strains
Stress, Physiological - blood
Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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Summary:Effects of acute and chronic cold stress on glutathione and related enzymes in rat erythrocytes were investigated. Blood from both cold-acclimated (CA) and cold-adapted (CG) rats had significantly lower concentrations of glutathione than blood from control animals. Superoxide dismutase activity was increased significantly in CA rats and tended to rise in CG rats. Activity of glutathione peroxidase in erythrocytes was inconsistent in that it tended to increase in CA rats but decreased significantly in CG rats. The results may imply that CG rats suffered deleterious effects of hydrogen peroxide. On the other hand, there were marked decreases in glutathione peroxidase and glutathione reductase activities in acutely cold-exposed rats in conjunction with unchanged levels of glutathione. In all treatments the state of riboflavin metabolism was estimated to be adequate, since no increases were observed in the erythrocyte glutathione reductase activity coefficient.
ISSN:0020-7128
1432-1254
DOI:10.1007/bf01087487