Effect of pineal tetrapeptide on antioxidant defense in Drosophila melanogaster

Effects of synthetic pineal tetrapeptide L-Ala-L-Glu-L-Asp-L-Glu (Epithalon) on specific catalase activity and the content of conjugated hydroperoxides in highly inbred Drosophila melanogaster lines differing in reproductive functions were studied. It was shown that Epithalon is a potent modulator o...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-04, Vol.129 (4), p.355-356
Main Authors: Khavinson, V K, Myl'nikov, S V
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Antioxidants - pharmacology
Catalase - physiology
Drosophila melanogaster - physiology
Free Radicals
Peptides - pharmacology
Pineal Gland - physiology
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Summary:Effects of synthetic pineal tetrapeptide L-Ala-L-Glu-L-Asp-L-Glu (Epithalon) on specific catalase activity and the content of conjugated hydroperoxides in highly inbred Drosophila melanogaster lines differing in reproductive functions were studied. It was shown that Epithalon is a potent modulator of the antioxidant defense, whose biological activity 1000-fold surpasses that of the complex pineal peptide preparation Epithalamin.
ISSN:0007-4888
DOI:10.1007/BF02439268