Abnormal propagation pattern of duodenal pressure waves in the irritable bowel syndrome (IBD)

The propagation pattern of individual pressure waves in the gastroduodenal area in IBS is unexplored. We performed antroduodenojejunal manometry on 26 patients with IBS--13 with diarrhea predominant IBS (IBS-D) and 13 with constipation predominant IBS (IBS-C)--and 32 healthy controls. Neuropathic-li...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 2000-11, Vol.45 (11), p.2151-2161
Main Authors: SIMREN, Magnus, CASTEDAL, Maria, SVEDLUND, Jan, ABRAHAMSSON, Hasse, BJORNSSON, Einar
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Colonic Diseases, Functional - diagnosis
Colonic Diseases, Functional - physiopathology
Constipation - physiopathology
Diarrhea - physiopathology
Duodenum - physiopathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Motility - physiology
Humans
Male
Manometry
Medical sciences
Middle Aged
Other diseases. Semiology
Reference Values
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The propagation pattern of individual pressure waves in the gastroduodenal area in IBS is unexplored. We performed antroduodenojejunal manometry on 26 patients with IBS--13 with diarrhea predominant IBS (IBS-D) and 13 with constipation predominant IBS (IBS-C)--and 32 healthy controls. Neuropathic-like motor abnormalities were found in 38% of the patients with conventional manometric evaluation. With high-resolution analysis additional abnormalities were observed in the majority of the patients, with increased frequency of retrograde pressure waves postprandially in both IBS subgroups and in phase II in IBS-D. A correlation between subjective gastrointestinal symptoms and the frequency of retrograde pressure waves in phase II in IBS-D was demonstrated. Motility indices and the number of long clusters were also higher in patients compared to controls. To conclude, an abnormal propagation pattern of individual duodenal pressure waves in IBS patients was demonstrated and found to be related to symptom severity in diarrhea-predominant IBS. High-resolution analysis adds information to standard manometry.
ISSN:0163-2116
1573-2568
DOI:10.1023/a:1010770302403