Excretion patterns of mucosally delivered antibodies to p23 in Cryptosporidium parvum infected calves

Fecal samples obtained at intervals from six calves with acute cryptosporidiosis contained antibodies of multiple isotypes to p23. IgM-, IgA-, and IgG 1-isotype anti-p23 appeared before IgG 2-isotype antibodies. All anti-p23 antibodies had declined by 2 months after infection. One calf that failed t...

Full description

Saved in:
Bibliographic Details
Published in:Veterinary immunology and immunopathology 2000-10, Vol.76 (3), p.309-317
Main Authors: Wyatt, Carol R., Brackett, E.Joan, Mason, Patricia H., Savidge, Jennifer, Perryman, Lance E.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Anti-p23
Antibodies, Protozoan - immunology
Antibodies, Protozoan - physiology
Calves
Cattle
Cattle Diseases - immunology
Cattle Diseases - parasitology
Cryptosporidiosis
Cryptosporidiosis - immunology
Cryptosporidiosis - parasitology
Cryptosporidiosis - veterinary
Cryptosporidium parvum
Cryptosporidium parvum - growth & development
Cryptosporidium parvum - immunology
Excretion patterns
Feces - parasitology
Flow Cytometry - veterinary
Immunity, Mucosal - physiology
Immunoassay - veterinary
Immunoglobulin Isotypes - immunology
Immunoglobulin Isotypes - physiology
Male
Microspheres
Mucosal antibodies
Specific Pathogen-Free Organisms
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fecal samples obtained at intervals from six calves with acute cryptosporidiosis contained antibodies of multiple isotypes to p23. IgM-, IgA-, and IgG 1-isotype anti-p23 appeared before IgG 2-isotype antibodies. All anti-p23 antibodies had declined by 2 months after infection. One calf that failed to shed oocysts following initial exposure developed IgG 1-isotype anti-p23 antibodies. One calf that died following exposure to Cryptosporidium parvum oocysts lacked detectable anti-p23 antibodies. Re-inoculation with C. parvum resulted in a brief, marked recall response to p23.
ISSN:0165-2427
1873-2534
DOI:10.1016/S0165-2427(00)00218-X