Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma

Experiments in CBA mice with transplanted CaO 1 ovarian carcinoma possessing common antigenic determinants with human ovarian carcinoma showed that specific immunotherapy with mucin containing CA 125 antigen inhibited tumor growth by 60% and prolonged animal lifespan by 40-60% in comparison with the...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-04, Vol.129 (4), p.383-385
Main Authors: Amandzholov, B S, Sitdikova, S M, Lebedin, Y S, Chukanov, S V, Toptygin, A Y, Manzyuk, L V, Donenko, F V
Format: Article
Language:English
Subjects:
Animals
Antigen (tumor-associated)
Antigenic determinants
Antigens
Antitumor activity
CA-125 Antigen - immunology
CA-125 Antigen - therapeutic use
Female
Humans
Immunoglobulin G
Immunoglobulin M
Immunotherapy
Life span
Mice
Mice, Inbred CBA
mucin
Mucins - immunology
Mucins - therapeutic use
Neoplasm Transplantation
Ovarian cancer
Ovarian carcinoma
Ovarian Neoplasms - immunology
Ovarian Neoplasms - therapy
Titration
Tumors
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Summary:Experiments in CBA mice with transplanted CaO 1 ovarian carcinoma possessing common antigenic determinants with human ovarian carcinoma showed that specific immunotherapy with mucin containing CA 125 antigen inhibited tumor growth by 60% and prolonged animal lifespan by 40-60% in comparison with the control. The correlation coefficient between the tumor size and antibody titer after injection of mucin was -0.4 for IgM and -0.6 for IgG. Titration of IgG may be used for monitoring of the efficiency of specific immunotherapy.
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02439278