Involvement of bone marrow fibroblasts in the recovery of granulocytopoiesis after cytostatic-induced myelosuppression

The effects of anticancer drugs whose action is mediated by different mechanisms on activity of bone marrow fibroblasts and their role in the regulation of granulocytopoiesis recovery after cytostatic treatment were studied. The antimetabolite 5-fluorouracil strongly suppressed, while the anthracycl...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-05, Vol.129 (5), p.445-448
Main Authors: Dygaii, A M, Zhdanov, V V, Pozhen'ko, N S, Gur'yantseva, L A, Gol'dberg, E D
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Bone marrow
Bone Marrow Cells - pathology
Bone Marrow Cells - physiology
Cell Differentiation
Fibroblasts - pathology
Fibroblasts - physiology
Granulocytes - pathology
Granulocytes - physiology
Hematopoiesis
Male
Mice
Mice, Inbred CBA
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Summary:The effects of anticancer drugs whose action is mediated by different mechanisms on activity of bone marrow fibroblasts and their role in the regulation of granulocytopoiesis recovery after cytostatic treatment were studied. The antimetabolite 5-fluorouracil strongly suppressed, while the anthracycline antibiotic adriamycin and the alkylating agent cyclophosphamide stimulated function of stromal cells. This largely accounted for different dynamics of recovery of the bone marrow neutrophil lineage.
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02439797