Biosynthesis of IC202C, a new siderophore with immunosuppressive activity

In the course of our screening program for low molecular weight immunosuppressive compounds, IC202A (1), B (2) and C (3) have been isolated from the culture filtrate of Streptoalloteichus sp. 1454-19. They are structurally characteristic in terminal moieties such as butylidene-N-oxide, nitro and ald...

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Bibliographic Details
Published in:Journal of antibiotics 2000-12, Vol.53 (12), p.1411-1415
Main Authors: IIJIMA, Masatomi, SOMENO, Tetsuya, AMEMIYA, Masahide, ISHIZUKA, Masaaki, NAGANAWA, Hiroshi, TAKEUCHI, Tomio
Format: Article
Language:English
Subjects:
Actinomycetales - metabolism
Amides - chemistry
Amides - metabolism
Biological and medical sciences
Hydroxamic Acids - chemistry
Hydroxamic Acids - metabolism
IC202s
Immunomodulators
Immunosuppressive Agents - chemistry
Immunosuppressive Agents - metabolism
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacology. Drug treatments
Siderophores - chemistry
Siderophores - metabolism
Spectrometry, Mass, Fast Atom Bombardment
Streptoalloteichus
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Summary:In the course of our screening program for low molecular weight immunosuppressive compounds, IC202A (1), B (2) and C (3) have been isolated from the culture filtrate of Streptoalloteichus sp. 1454-19. They are structurally characteristic in terminal moieties such as butylidene-N-oxide, nitro and aldoxime groups, respectively. Of these compounds, IC202C (3) showed the most potent immunosuppressive activity and was produced as the major compound in the fermentation broth. However, the amounts of IC202s were very low for the evaluation of in vivo experiments. Thus, it is necessary to know the optimum fermentation condition and biosynthetic route for the increment of IC202s.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.1411