p53 and Bcl-2 oncoprotein expression in placentas with hydropic changes and partial and complete moles

Forty molar and non‐molar placentas with hydropic changes (14 complete moles, 14 partial moles, and 12 hydropic non‐molar placentas) were examined immunohistochemically for expression of oncoproteins p53 and Bcl‐2. The data were evaluated to determine if p53 and Bcl‐2 expression could aid in differe...

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Bibliographic Details
Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2000-11, Vol.108 (11), p.756-760
Main Author: Al-Bozom, ISSAM A.
Format: Article
Language:English
Subjects:
abortuses with hydropic changes
Bcl-2
Biological and medical sciences
Biomarkers - analysis
complete hydatidiform mole
Diseases of mother, fetus and pregnancy
Female
Gynecology. Andrology. Obstetrics
Humans
Hydatidiform Mole - chemistry
Hydatidiform Mole - diagnosis
Hydrops Fetalis - diagnosis
Hydrops Fetalis - metabolism
Immunohistochemistry
Medical sciences
p53
partial hydatidiform mole
Placenta - chemistry
Pregnancy
Pregnancy. Fetus. Placenta
Proto-Oncogene Proteins c-bcl-2 - analysis
Trophoblasts - chemistry
Tumor Suppressor Protein p53 - analysis
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Summary:Forty molar and non‐molar placentas with hydropic changes (14 complete moles, 14 partial moles, and 12 hydropic non‐molar placentas) were examined immunohistochemically for expression of oncoproteins p53 and Bcl‐2. The data were evaluated to determine if p53 and Bcl‐2 expression could aid in differentiating molar from non‐molar pregnancies on the one hand and complete mole from partial mole on the other. Thirteen out of fourteen complete moles showed p53 expression (93%), 8 of the 14 partial moles expressed p53 (57%), and none of the non‐molar pregnancies expressed p53 in the extravillous intermediate trophoblasts. Regarding Bcl‐2, the syncytiotrophoblasts of most molar and non‐molar placentas showed strong and diffuse positivity. These results suggest that p53 expression can be used as a distinguishing parameter between complete moles and placentas with hydropic changes on the one hand and to a lesser extent between partial moles and placentas with hydropic changes on the other hand. Bcl‐2 cannot be used in the same way as p53.
ISSN:0903-4641
1600-0463
DOI:10.1034/j.1600-0463.2000.d01-25.x