Annular leukocytoclastic vasculitis associated with monoclonal gammopathy of unknown significance

Leukocytoclastic vasculitis is a condition characterized by necrotizing neutrophilic inflammation of small dermal blood vessels usually resulting in palpable purpuric lesions. Leukocytoclastic vasculitis may be secondary to a variety of medications and underlying disease processes, including infecti...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2000-11, Vol.43 (5), p.955-957
Main Authors: Nousari, Hossein C., Kimyai-Asadi, Arash, Stone, John H.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Diagnosis, Differential
Female
Humans
Medical sciences
Monoclonal Gammopathy of Undetermined Significance - complications
Monoclonal Gammopathy of Undetermined Significance - pathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Skin - pathology
Skin Diseases, Vascular - complications
Skin Diseases, Vascular - pathology
Vasculitis, Leukocytoclastic, Cutaneous - complications
Vasculitis, Leukocytoclastic, Cutaneous - diagnosis
Vasculitis, Leukocytoclastic, Cutaneous - pathology
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Summary:Leukocytoclastic vasculitis is a condition characterized by necrotizing neutrophilic inflammation of small dermal blood vessels usually resulting in palpable purpuric lesions. Leukocytoclastic vasculitis may be secondary to a variety of medications and underlying disease processes, including infections, connective tissue disorders, and malignancies. We describe a patient with a monoclonal gammopathy of unknown significance in whom leukocytoclastic vasculitis developed, manifested by a few prominent annular plaques on the lower extremity. The rare association between monoclonal gammopathy of unknown significance and leukocytoclastic vasculitis as well as the unusual annular presentation of the disease in this patient is discussed, and the relevant literature is reviewed. (J Am Acad Dermatol 2000;43:955-7.)
ISSN:0190-9622
1097-6787
DOI:10.1067/mjd.2000.103643